RRC ID 38327
Author Shintani S, Hamakawa H, Nakashiro K, Shirota T, Hatori M, Tanaka M, Kuroshita Y, Kurokawa Y.
Title Friend leukaemia insertion (Fli)-1 is a prediction marker candidate for radiotherapy resistant oral squamous cell carcinoma.
Journal Int J Oral Maxillofac Surg
Abstract Radiotherapy is commonly used to treat oral squamous cell carcinoma (OSCC), but its therapeutic effects are unpredictable. To determine which genes correlate with radiation resistance in oral cancer, the authors evaluated radiation sensitivity using a standard colony formation assay with a gene microarray system for seven OSCC cell lines. They found significant associations between dozens of gene-expression levels and radiation resistance of OSCC cell lines. Following analysis of the different radiosensitive cancer cell lines, the friend leukaemia insertion (Fli)-1 gene was selected as a prediction marker gene for OSCC radiotherapy resistance. Fli-1 expression was associated with radiation resistance in OSCC patients. These data help to predict the effects radiation therapy has on OSCC, in turn contributing to the development of alternative radiation therapies.
Volume 39(11)
Pages 1115-9
Published 2010-11
DOI 10.1016/j.ijom.2010.02.027
PII S0901-5027(10)00304-8
PMID 20709497
MeSH Biomarkers, Tumor / metabolism* Carcinoma, Squamous Cell / genetics Carcinoma, Squamous Cell / metabolism* Carcinoma, Squamous Cell / radiotherapy Cell Line, Tumor Gene Expression Profiling Humans Microarray Analysis Mouth Neoplasms / genetics Mouth Neoplasms / metabolism* Mouth Neoplasms / radiotherapy Predictive Value of Tests Proto-Oncogene Protein c-fli-1 / metabolism*
IF 1.961
Times Cited 7
Human and Animal Cells