| RRC ID |
38382
|
| Author |
Mellati A, Valizadeh Kiamahalleh M, Dai S, Bi J, Jin B, Zhang H.
|
| Title |
Influence of polymer molecular weight on the in vitro cytotoxicity of poly (N-isopropylacrylamide).
|
| Journal |
Mater Sci Eng C Mater Biol Appl
|
| Abstract |
Poly (N-isopropylacrylamide) (PNIPAAm) is a thermosensitive polymer with various biomedical applications. We examined molecular weight (MW)-dependent cytotoxicity of PNIPAAm. Our results indicated that low-MW PNIPAAm (degree of polymerization (DP)=35) is inherently toxic to cells. Moderate-MW PNIPAAms with their DP between 100 and 200 are non-cytotoxic. When cells are seeded on top of a polymer-coated surface, PNIPAAm with a higher MW (DP=400) shows non/low cytotoxicity, while when monolayer cells are exposed to the polymer solution, cell viability drops drastically. This may be due to lack of nutrient and oxygen rather than intrinsic toxicity of the polymer.
|
| Volume |
59
|
| Pages |
509-513
|
| Published |
2016-2-1
|
| DOI |
10.1016/j.msec.2015.10.043
|
| PII |
S0928-4931(15)30474-4
|
| PMID |
26652402
|
| MeSH |
Acrylic Resins / chemistry*
Acrylic Resins / toxicity*
Cell Line
Cell Survival / drug effects*
Drug Delivery Systems
HEK293 Cells
HeLa Cells
Humans
Molecular Weight
Temperature
|
| IF |
5.88
|
| Times Cited |
13
|
|
WOS Category
|
MATERIALS SCIENCE, BIOMATERIALS
|
| Resource |
| Human and Animal Cells |
10T1/2(RCB0247) |
