論文 - 詳細
| RRC ID | 38607 |
|---|---|
| 著者 | Takechi S, Ito S, Kashige N, Ishida T, Yamaguchi T. |
| タイトル | Glutathione depression by dihydropyrazine derivative. |
| ジャーナル | J Toxicol Sci |
| Abstract |
Dihydropyrazine (DHP), which is formed by nonenzymatic glycation, generates various radical species that lead to DNA damage and enzyme inhibition. In this study, we examined the reaction between DHP derivatives and glutathione (GSH). DHP exposure caused more intense growth inhibition of a GSH-deficient mutant Escherichia coli strain compared with the wild-type strain. DHP-exposed mouse fibroblasts showed a decrease in the cellular GSH level. The obtained data suggested that the reaction of DHP with GSH possibly potentiates cellular stress via the depletion of cellular GSH levels. |
| 巻・号 | 36(2) |
| ページ | 231-5 |
| 公開日 | 2011-4-1 |
| DOI | 10.2131/jts.36.231 |
| PII | JST.JSTAGE/jts/36.231 |
| PMID | 21467750 |
| MeSH | 3T3 Cells Animals Escherichia coli / drug effects Escherichia coli / growth & development Fibroblasts / drug effects Fibroblasts / metabolism Glutathione / metabolism* Mice Oxidation-Reduction Oxidative Stress / drug effects* Pyrazines / metabolism* Pyrazines / toxicity* Reactive Oxygen Species / metabolism |
| IF | 1.737 |
| 引用数 | 3 |
| WOS 分野 | TOXICOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |