論文 - 詳細
| RRC ID | 38641 |
|---|---|
| 著者 | Shioi A, Teitelbaum SL, Ross FP, Welgus HG, Suzuki H, Ohara J, Lacey DL. |
| タイトル | Interleukin 4 inhibits murine osteoclast formation in vitro. |
| ジャーナル | J Cell Biochem |
| Abstract |
Interleukin 4 (IL-4) is a product of activated T cells and mast cells with effects on immunologic and hematopoietic processes. We now report that IL-4 inhibits the formation of osteoclasts from murine bone marrow cells cocultured with stromal cells. Numerous (3,000-4,000 cells/2 cm2) tartrate-resistant acid-phosphatase-positive multinucleated cells with the capacity to generate cAMP in response to salmon calcitonin (ED50 = 10(-10) M) developed within 10-12 days of culture. IL-4 (ID50 = 10 U/ml) inhibited osteoclast generation in doses similar to those that induce proliferation of IL-4-responsive T cells. Additionally, the rat antimurine IL-4 monoclonal antibody 11B11 antagonizes the IL-4-inhibitory effect on osteoclast formation. These results suggest that IL-4 impedes agonist-induced in vitro bone resorption by inhibiting osteoclastogenesis. |
| 巻・号 | 47(3) |
| ページ | 272-7 |
| 公開日 | 1991-11-1 |
| DOI | 10.1002/jcb.240470313 |
| PMID | 1665152 |
| MeSH | Animals Antibodies, Monoclonal Biomarkers Bone Marrow / drug effects* Bone Marrow Cells Bone Remodeling / physiology Calcitonin / pharmacology Cell Differentiation / drug effects Cell Division Cells, Cultured Cyclic AMP / metabolism Interleukin-4 / immunology Interleukin-4 / pharmacology* Lymphocyte Activation / physiology Mice Osteoclasts / drug effects* T-Lymphocytes / cytology T-Lymphocytes / drug effects |
| IF | 4.237 |
| 引用数 | 74 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | ST2(RCB0224) |