| RRC ID |
38679
|
| Author |
Ohkuma S, Shimizu S, Noto M, Sai Y, Kinoshita K, Tamura H.
|
| Title |
Inhibition of cell growth by bafilomycin A1, a selective inhibitor of vacuolar H(+)-ATPase.
|
| Journal |
In Vitro Cell Dev Biol Anim
|
| Abstract |
Bafilomycin A1, a potent selective inhibitor of vacuolar H(+)-ATPase, inhibited the growth of a variety of cultured cells dose-dependently, including golden hamster embryo and NIH-3T3 fibroblasts, whether or not they were transformed, and PC12 and HeLa cells. The concentration of bafilomycin A1 for 50% inhibition of cell growth ranged from 10 to 50 nM. The dose response was nearly parallel with that of the bafilomycin A1-induced lysosomal pH increase. The degree of pH increase for growth inhibition produced by bafilomycin A1 was similar to that produced by NH4Cl in which little difference was recognized in effect among cell types.
|
| Volume |
29A(11)
|
| Pages |
862-6
|
| Published |
1993-11-1
|
| DOI |
10.1007/BF02631364
|
| PMID |
8167902
|
| MeSH |
3T3 Cells
Ammonium Chloride / pharmacology
Animals
Anti-Bacterial Agents / pharmacology*
CHO Cells
Cell Division / drug effects*
Cell Line, Transformed
Cricetinae
HeLa Cells
Humans
Hydrogen-Ion Concentration
Lysosomes / drug effects
Lysosomes / metabolism
Macrolides*
Mice
PC12 Cells
Proton-Translocating ATPases / antagonists & inhibitors*
Vacuoles / drug effects
Vacuoles / enzymology*
|
| IF |
1.665
|
| Times Cited |
38
|
|
WOS Category
|
CELL BIOLOGY
DEVELOPMENTAL BIOLOGY
|
| Resource |
| Human and Animal Cells |
PC-12(RCB0009) |
