RRC ID 38735
著者 Kondo S, Yin D, Takeuchi J, Morimura T, Miyatake SI, Nakatsu S, Oda Y, Kikuchi H.
タイトル Tumour necrosis factor-alpha induces an increase in susceptibility of human glioblastoma U87-MG cells to natural killer cell-mediated lysis.
ジャーナル Br J Cancer
Abstract The mechanism by which tumour necrosis factor (TNF)-alpha increases the susceptibility of U87-MG human glioblastoma cells to lysis by natural killer (NK) cells was studied. Treatment with TNF-alpha (100 units ml-1) for 48 h enhanced the susceptibility of tumour cells to lysis by NK cells. Increased susceptibility to lysis was associated with enhanced expression of intercellular adhesion molecule 1 (ICAM-1) and HLA class I antigen. Antisense ICAM-1 oligonucleotide inhibited lysis by NK cells of TNF-alpha-treated tumour cells. In contrast, acid treatment following TNF-alpha treatment increased lysis by NK cells. These findings indicate that TNF-alpha treatment of glioblastoma cells increased their susceptibility to lysis by NK cells, since ICAM-1 up-regulation would have more profound effects on NK susceptibility than would HLA class I antigen up-regulation.
巻・号 69(4)
ページ 627-32
公開日 1994-4-1
DOI 10.1038/bjc.1994.123
PMID 7908214
PMC PMC1968817
MeSH Antigens, Neoplasm / biosynthesis Antigens, Neoplasm / immunology Base Sequence Cell Adhesion Molecules / biosynthesis Cell Adhesion Molecules / immunology Cytotoxicity, Immunologic / drug effects* Fluorescent Antibody Technique Glioblastoma / immunology* Glioblastoma / pathology Histocompatibility Antigens Class I / biosynthesis Histocompatibility Antigens Class I / immunology Humans Intercellular Adhesion Molecule-1 Killer Cells, Natural / physiology* Molecular Sequence Data Oligonucleotides, Antisense / metabolism Tumor Cells, Cultured / drug effects Tumor Cells, Cultured / immunology Tumor Necrosis Factor-alpha / pharmacology* Up-Regulation
IF 5.791
引用数 19
WOS 分野 ONCOLOGY
リソース情報
ヒト・動物細胞 U-87 MG(RCB0419)