論文 - 詳細
| RRC ID | 38735 |
|---|---|
| 著者 | Kondo S, Yin D, Takeuchi J, Morimura T, Miyatake SI, Nakatsu S, Oda Y, Kikuchi H. |
| タイトル | Tumour necrosis factor-alpha induces an increase in susceptibility of human glioblastoma U87-MG cells to natural killer cell-mediated lysis. |
| ジャーナル | Br J Cancer |
| Abstract |
The mechanism by which tumour necrosis factor (TNF)-alpha increases the susceptibility of U87-MG human glioblastoma cells to lysis by natural killer (NK) cells was studied. Treatment with TNF-alpha (100 units ml-1) for 48 h enhanced the susceptibility of tumour cells to lysis by NK cells. Increased susceptibility to lysis was associated with enhanced expression of intercellular adhesion molecule 1 (ICAM-1) and HLA class I antigen. Antisense ICAM-1 oligonucleotide inhibited lysis by NK cells of TNF-alpha-treated tumour cells. In contrast, acid treatment following TNF-alpha treatment increased lysis by NK cells. These findings indicate that TNF-alpha treatment of glioblastoma cells increased their susceptibility to lysis by NK cells, since ICAM-1 up-regulation would have more profound effects on NK susceptibility than would HLA class I antigen up-regulation. |
| 巻・号 | 69(4) |
| ページ | 627-32 |
| 公開日 | 1994-4-1 |
| DOI | 10.1038/bjc.1994.123 |
| PMID | 7908214 |
| PMC | PMC1968817 |
| MeSH | Antigens, Neoplasm / biosynthesis Antigens, Neoplasm / immunology Base Sequence Cell Adhesion Molecules / biosynthesis Cell Adhesion Molecules / immunology Cytotoxicity, Immunologic / drug effects* Fluorescent Antibody Technique Glioblastoma / immunology* Glioblastoma / pathology Histocompatibility Antigens Class I / biosynthesis Histocompatibility Antigens Class I / immunology Humans Intercellular Adhesion Molecule-1 Killer Cells, Natural / physiology* Molecular Sequence Data Oligonucleotides, Antisense / metabolism Tumor Cells, Cultured / drug effects Tumor Cells, Cultured / immunology Tumor Necrosis Factor-alpha / pharmacology* Up-Regulation |
| IF | 5.791 |
| 引用数 | 19 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | U-87 MG(RCB0419) |