論文 - 詳細
| RRC ID | 38759 |
|---|---|
| 著者 | Maruyama K, Tsukada T, Bandoh S, Sasaki K, Ohkura N, Yamaguchi K. |
| タイトル | Expression of NOR-1 and its closely related members of the steroid/thyroid hormone receptor superfamily in human neuroblastoma cell lines. |
| ジャーナル | Cancer Lett |
| Abstract |
Previously, we isolated a cDNA of neuron derived orphan receptor (NOR-1), a putative transcription factor with strong homologies to the orphan nuclear receptors NGFI-B and NURR1. In the present study, we examined the gene expression of NOR-1 as well as NGFI-B and NURR1 in human neuroblastoma cell lines by reverse transcription-polymerase chain reaction and nucleotide sequencing. Although the mRNAs of these orphan receptors were detected in all six neuroblastoma cell lines examined, basal expression levels of these genes varied among cell lines. Treatment with forskolin and 12-O-tetradecanoylphorbol-13-acetate rapidly increased the expression of all these genes in neuroblastoma NB-OK-1 cells. This induction did not require de novo protein synthesis, indicating that the NOR-1 gene as well as NGFI-B and NURR1 genes is an immediate-early gene. This is the first demonstration of NOR-1 gene expression in tumor cell lines. |
| 巻・号 | 96(1) |
| ページ | 117-22 |
| 公開日 | 1995-9-4 |
| DOI | 10.1016/0304-3835(95)03921-i |
| PII | 030438359503921I |
| PMID | 7553599 |
| MeSH | Base Sequence Cell Differentiation / drug effects Cell Line Colforsin / pharmacology Cycloheximide / pharmacology DNA Primers / chemistry DNA-Binding Proteins / genetics Gene Expression Humans Molecular Sequence Data Nerve Tissue Proteins / genetics Neuroblastoma / genetics* Nuclear Receptor Subfamily 4, Group A, Member 1 Nuclear Receptor Subfamily 4, Group A, Member 2 RNA, Messenger / genetics RNA, Neoplasm / genetics Receptors, Cytoplasmic and Nuclear Receptors, Steroid / genetics* Receptors, Thyroid Hormone / genetics* Tetradecanoylphorbol Acetate / pharmacology Transcription Factors / genetics Tumor Cells, Cultured |
| IF | 7.36 |
| 引用数 | 42 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | LA-N-1(RCB0483) LA-N-2(RCB0484) LA-N-5(RCB0485) |