論文 - 詳細
| RRC ID | 38935 |
|---|---|
| 著者 | Nakajima M, Shinoda I, Samejima Y, Miyauchi H, Fukuwatari Y, Hayasawa H. |
| タイトル | Kappa-casein suppresses melanogenesis in cultured pigment cells. |
| ジャーナル | Pigment Cell Res |
| Abstract |
The effects of bovine milk proteins on melanogenesis in B16 cells were examined. Both whey protein isolate and casein exhibited depigmenting properties. Among the major protein components of milk--including beta-lactoglobulin, alpha-lactalbumin, alpha-, beta-, and kappa-casein--only kappa-casein exhibited the depigmenting effect. However, the carboxyl terminal peptide of kappa-casein, glycomacropeptide, did not show this activity. Also, kappa-casein promoted the proliferation of the cells and inhibited the activity of tyrosinase in the cells. These results indicate that kappa-casein acts as a melanogenesis-suppressing modulator. |
| 巻・号 | 9(5) |
| ページ | 235-9 |
| 公開日 | 1996-10-1 |
| DOI | 10.1111/j.1600-0749.1996.tb00112.x |
| PMID | 9014209 |
| MeSH | Animals Caseins / pharmacology* Cattle Cell Division Melanins / analysis Melanocytes / cytology Melanocytes / drug effects* Melanocytes / enzymology Melanoma Mice Milk Proteins / pharmacology Monophenol Monooxygenase / metabolism Pigmentation / drug effects* Tumor Cells, Cultured Whey Proteins |
| 引用数 | 9 |
| WOS 分野 | DERMATOLOGY CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | B16 melanoma 4A5(RCB0557) |