Reference - Detail
|Author||Bae YK, Shimizu T, Muraoka O, Yabe T, Hirata T, Nojima H, Hirano T, Hibi M.|
|Title||Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish.|
|Journal||Gene Expr. Patterns|
sax1/nkx1.2 and sax2/nkx1.1 are members of the evolutionally conserved NK-1 homeobox gene family. sax1/nkx1.2 is reported to be expressed in the central nervous system during early and late neurogenesis in the chick and mouse, but the expression of sax2/nkx1.1 has not been reported. We isolated zebrafish cDNAs for sax1/nkx1.2 and sax2/nkx1.1 and examined their expression. In zebrafish, unlike chick and mouse, sax1/nkx1.2 was expressed in the prospective medial floor plate from the mid-gastrula period and was dependent on Nodal signaling. From the early segmentation period, sax1/nkx1.2 was also expressed in the posterior neuroectoderm. sax2/nkx1.1 was expressed in the prospective extraocular muscles, mesencephalic neurons residing along the tract of the posterior commissure, ventral neurons in the hindbrain, and interneurons in the spinal cord.
|MeSH||Animals Central Nervous System / embryology* Gene Expression Regulation, Developmental / genetics Gene Expression Regulation, Developmental / physiology* Homeodomain Proteins / biosynthesis* Homeodomain Proteins / genetics Humans Molecular Sequence Data Nodal Protein Signal Transduction / physiology Transcription Factors / biosynthesis* Transcription Factors / genetics Transforming Growth Factor beta / metabolism Zebrafish / embryology* Zebrafish / genetics Zebrafish Proteins / biosynthesis* Zebrafish Proteins / genetics|
|WOS Category||GENETICS & HEREDITY DEVELOPMENTAL BIOLOGY|