論文 - 詳細
| RRC ID | 39051 |
|---|---|
| 著者 | Kanamori M, Kai C, Hayashizaki Y, Suzuki H. |
| タイトル | NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6. |
| ジャーナル | FEBS Lett |
| Abstract |
NF-kappaB activator 1 (Act1), also called CIKS, is a recently identified protein with NF-kappaB and AP-1 activation activities through its association with the IkappaB kinase complex. We identified and confirmed that Act1 interacts with tumor necrosis factor receptor-associated factor 6 (TRAF6); notably, Act1 binds to TRAF6 only among TRAF family proteins. The amino-terminal half of Act1 is required for its interaction with the TRAF domain. Act1-mediated NF-kappaB activation was inhibited by a dominant-negative mutant of TRAF6 in a dose-dependent manner, and IL-1-induced NF-kappaB activation was inhibited by a high level of Act1 expression. Our results suggest that Act1 is involved in IL-1/Toll-mediated signaling through TRAF6. |
| 巻・号 | 532(1-2) |
| ページ | 241-6 |
| 公開日 | 2002-12-4 |
| DOI | 10.1016/s0014-5793(02)03688-8 |
| PII | S0014579302036888 |
| PMID | 12459498 |
| MeSH | Adaptor Proteins, Signal Transducing* Carrier Proteins / metabolism* Cell Line Drosophila Proteins* Humans Interleukin-1 / pharmacology* Membrane Glycoproteins / metabolism Models, Biological Mutation NF-kappa B / metabolism* Protein Structure, Tertiary Proteins / chemistry Proteins / genetics Proteins / metabolism* Receptors, Cell Surface / metabolism Signal Transduction* TNF Receptor-Associated Factor 6 Toll-Like Receptors Tumor Necrosis Factor Receptor-Associated Peptides and Proteins Two-Hybrid System Techniques |
| IF | 3.057 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | CHO-K1(RCB0285) |