| RRC ID |
39330
|
| Author |
Moriyama T, Kataoka H, Hamasuna R, Yoshida E, Sameshima T, Iseda T, Yokogami K, Nakano S, Koono M, Wakisaka S.
|
| Title |
Simultaneous up-regulation of urokinase-type plasminogen activator (uPA) and uPA receptor by hepatocyte growth factor/scatter factor in human glioma cells.
|
| Journal |
Clin Exp Metastasis
|
| Abstract |
Several lines of evidence indicate that hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, c-Met, may play an important role in progression of human glioma. In this study, effects of HGF/SF on urokinase- type plasminogen activator (uPA)-mediated proteolysis network were examined in c-Met-positive human glioma cell lines. Treatment of the glioma cells with various concentrations of HGF/SF resulted in an enhanced secretion of uPA proteins accompanying increased transcription of uPA mRNA in a dose dependent fashion. The levels of uPA receptor (uPAR) mRNAs were also elevated simultaneously upon HGF/SF stimulation, and the cell-surface associated uPA activity was also elevated by the treatment. Since concomitant expression of HGF and its receptor c-Met are frequently observed in malignant gliomas, these results suggest that HGF/SF participates in invasive process of malignant glioma cells not only by its motility-stimulating activity but also through enhanced degradation of the extracellular matrix induced by autocrine activation of uPA proteolysis network.
|
| Volume |
17(10)
|
| Pages |
873-9
|
| Published |
1999-1-1
|
| DOI |
10.1023/a:1006729611241
|
| PMID |
11089886
|
| MeSH |
Central Nervous System Neoplasms / drug therapy
Central Nervous System Neoplasms / metabolism*
Glioma / drug therapy
Glioma / metabolism*
Hepatocyte Growth Factor / metabolism*
Hepatocyte Growth Factor / pharmacology
Humans
Oligopeptides / metabolism
Proto-Oncogene Proteins c-met / metabolism
Receptors, Cell Surface / drug effects
Receptors, Cell Surface / genetics
Receptors, Cell Surface / metabolism*
Receptors, Urokinase Plasminogen Activator
Tumor Cells, Cultured
Up-Regulation
Urokinase-Type Plasminogen Activator / drug effects
Urokinase-Type Plasminogen Activator / genetics
Urokinase-Type Plasminogen Activator / metabolism*
|
| IF |
3.027
|
| Times Cited |
24
|
|
WOS Category
|
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
U251(RCB0461) |
