論文 - 詳細
| RRC ID | 39421 |
|---|---|
| 著者 | Matsunaga Y, Honda Y, Honda S, Iwasaki T, Qadota H, Benian GM, Kawano T. |
| タイトル | Diapause is associated with a change in the polarity of secretion of insulin-like peptides. |
| ジャーナル | Nat Commun |
| Abstract |
The insulin/IGF-1 signalling (IIS) pathway plays an important role in the regulation of larval diapause, the long-lived growth arrest state called dauer arrest, in Caenorhabditis elegans. In this nematode, 40 insulin-like peptides (ILPs) have been identified as putative ligands of the IIS pathway; however, it remains unknown how ILPs modulate larval diapause. Here we show that the secretory polarity of INS-35 and INS-7, which suppress larval diapause, is changed in the intestinal epithelial cells at larval diapause. These ILPs are secreted from the intestine into the body cavity during larval stages. In contrast, they are secreted into the intestinal lumen and degraded during dauer arrest, only to be secreted into the body cavity again when the worms return to developmental growth. The process that determines the secretory polarity of INS-35 and INS-7, thus, has an important role in the modulation of larval diapause. |
| 巻・号 | 7 |
| ページ | 10573 |
| 公開日 | 2016-2-3 |
| DOI | 10.1038/ncomms10573 |
| PII | ncomms10573 |
| PMID | 26838180 |
| PMC | PMC4742890 |
| MeSH | Animals Blotting, Western Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Carboxylic Ester Hydrolases / genetics Carboxylic Ester Hydrolases / metabolism Cell Polarity* Epithelial Cells / metabolism* Growth and Development / genetics* Insulins Intestinal Mucosa / cytology Intestinal Mucosa / metabolism* Larva Life Cycle Stages Microscopy, Fluorescence Peptide Hormones / genetics Peptide Hormones / metabolism Receptor, Insulin / genetics Receptor, Insulin / metabolism Somatomedins / genetics* Somatomedins / metabolism |
| IF | 12.121 |
| 引用数 | 7 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| 線虫 | tm1907 tm2308 tm2416 |