| RRC ID |
395
|
| 著者 |
Aizawa H, Bianco IH, Hamaoka T, Miyashita T, Uemura O, Concha ML, Russell C, Wilson SW, Okamoto H.
|
| タイトル |
Laterotopic representation of left-right information onto the dorso-ventral axis of a zebrafish midbrain target nucleus.
|
| ジャーナル |
Curr Biol
|
| Abstract |
The habenulae are part of an evolutionarily highly conserved limbic-system conduction pathway that connects telencephalic nuclei to the interpeduncular nucleus (IPN) of the midbrain . In zebrafish, unilateral activation of the Nodal signaling pathway in the left brain specifies the laterality of the asymmetry of habenular size . We show "laterotopy" in the habenulo-interpeduncular projection in zebrafish, i.e., the stereotypic, topographic projection of left-sided habenular axons to the dorsal region of the IPN and of right-sided habenular axons to the ventral IPN. This asymmetric projection is accounted for by a prominent left-right (LR) difference in the size ratio of the medial and lateral habenular sub-nuclei, each of which specifically projects either to ventral or dorsal IPN targets. Asymmetric Nodal signaling directs the orientation of laterotopy but is dispensable for the establishment of laterotopy itself. Our results reveal a mechanism by which information distributed between left and right sides of the brain can be transmitted bilaterally without loss of LR coding, which may play a crucial role in functional lateralization of the vertebrate brain .
|
| 巻・号 |
15(3)
|
| ページ |
238-43
|
| 公開日 |
2005-2-8
|
| DOI |
10.1016/j.cub.2005.01.014
|
| PII |
S0960-9822(05)00040-0
|
| PMID |
15694307
|
| PMC |
PMC2790415
|
| MeSH |
Animals
Base Sequence
Brain Mapping*
DNA-Binding Proteins / genetics
Functional Laterality
Gene Library
Green Fluorescent Proteins
Habenula / anatomy & histology
Habenula / physiology*
In Situ Hybridization
Larva / anatomy & histology
Larva / physiology
Mesencephalon / anatomy & histology
Mesencephalon / physiology*
Molecular Sequence Data
Nodal Protein
Sequence Analysis, DNA
Signal Transduction / physiology*
Transcription Factor Brn-3
Transcription Factors / genetics
Transforming Growth Factor beta / metabolism
Transgenes / genetics
Zebrafish / anatomy & histology
Zebrafish / physiology*
|
| IF |
9.601
|
| 引用数 |
150
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ゼブラフィッシュ |
rw715
rw0
rw017
rw0110b |
