論文 - 詳細
| RRC ID | 395 |
|---|---|
| 著者 | Aizawa H, Bianco IH, Hamaoka T, Miyashita T, Uemura O, Concha ML, Russell C, Wilson SW, Okamoto H. |
| タイトル | Laterotopic representation of left-right information onto the dorso-ventral axis of a zebrafish midbrain target nucleus. |
| ジャーナル | Curr Biol |
| Abstract |
The habenulae are part of an evolutionarily highly conserved limbic-system conduction pathway that connects telencephalic nuclei to the interpeduncular nucleus (IPN) of the midbrain . In zebrafish, unilateral activation of the Nodal signaling pathway in the left brain specifies the laterality of the asymmetry of habenular size . We show "laterotopy" in the habenulo-interpeduncular projection in zebrafish, i.e., the stereotypic, topographic projection of left-sided habenular axons to the dorsal region of the IPN and of right-sided habenular axons to the ventral IPN. This asymmetric projection is accounted for by a prominent left-right (LR) difference in the size ratio of the medial and lateral habenular sub-nuclei, each of which specifically projects either to ventral or dorsal IPN targets. Asymmetric Nodal signaling directs the orientation of laterotopy but is dispensable for the establishment of laterotopy itself. Our results reveal a mechanism by which information distributed between left and right sides of the brain can be transmitted bilaterally without loss of LR coding, which may play a crucial role in functional lateralization of the vertebrate brain . |
| 巻・号 | 15(3) |
| ページ | 238-43 |
| 公開日 | 2005-2-8 |
| DOI | 10.1016/j.cub.2005.01.014 |
| PII | S0960-9822(05)00040-0 |
| PMID | 15694307 |
| PMC | PMC2790415 |
| MeSH | Animals Base Sequence Brain Mapping* DNA-Binding Proteins / genetics Functional Laterality Gene Library Green Fluorescent Proteins Habenula / anatomy & histology Habenula / physiology* In Situ Hybridization Larva / anatomy & histology Larva / physiology Mesencephalon / anatomy & histology Mesencephalon / physiology* Molecular Sequence Data Nodal Protein Sequence Analysis, DNA Signal Transduction / physiology* Transcription Factor Brn-3 Transcription Factors / genetics Transforming Growth Factor beta / metabolism Transgenes / genetics Zebrafish / anatomy & histology Zebrafish / physiology* |
| IF | 9.601 |
| 引用数 | 150 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | rw715 rw0 rw017 rw0110b |