| RRC ID |
39531
|
| 著者 |
Ogata S, Takeuchi M, Fujita H, Shibata K, Okumura K, Taguchi H.
|
| タイトル |
Apoptosis induced by niacin-related compounds in K562 cells but not in normal human lymphocytes.
|
| ジャーナル |
Biosci Biotechnol Biochem
|
| Abstract |
In our previous study, we found that niacin-related compounds induced apoptosis in human acute myelomonocytic leukemia cells, HL-60. We have investigated whether these compounds acted as inducers of apoptosis also in various other cell types. In human chronic myelogenous leukemia cells, K562, which are relatively resistant to various inducers of apoptosis, the apoptosis was induced by picolinic acid and dipicolinic acid in about 50% of the cells 5-10 mM via the caspase pathway, but was not at 1 mM. However, isonicotinamide did not induce apoptosis effectively in K562 cells. On the other hand, in normal human quiescent lymphocytes, the apoptosis was not induced by these compounds at the same concentrations. It is suggested that these compounds may induce apoptosis mainly in tumor cells. The change of intracellular peroxide levels was observed in the early phase of apoptosis induced by niacin-related compounds. We expect to make use of niacin-related compounds in the field of medicine.
|
| 巻・号 |
64(6)
|
| ページ |
1142-6
|
| 公開日 |
2000-6-1
|
| DOI |
10.1271/bbb.64.1142
|
| PMID |
10923782
|
| MeSH |
Antineoplastic Agents / pharmacology
Apoptosis / drug effects*
Humans
K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
Lymphocytes / cytology*
Lymphocytes / drug effects*
Lymphocytes / metabolism
Niacin / analogs & derivatives*
Niacin / pharmacology
Niacinamide / pharmacology
Peroxides / metabolism
Picolinic Acids / pharmacology
Reactive Oxygen Species / metabolism
|
| IF |
1.516
|
| 引用数 |
15
|
|
WOS 分野
|
CHEMISTRY, APPLIED
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
|
