論文 - 詳細
| RRC ID | 39531 |
|---|---|
| 著者 | Ogata S, Takeuchi M, Fujita H, Shibata K, Okumura K, Taguchi H. |
| タイトル | Apoptosis induced by niacin-related compounds in K562 cells but not in normal human lymphocytes. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
In our previous study, we found that niacin-related compounds induced apoptosis in human acute myelomonocytic leukemia cells, HL-60. We have investigated whether these compounds acted as inducers of apoptosis also in various other cell types. In human chronic myelogenous leukemia cells, K562, which are relatively resistant to various inducers of apoptosis, the apoptosis was induced by picolinic acid and dipicolinic acid in about 50% of the cells 5-10 mM via the caspase pathway, but was not at 1 mM. However, isonicotinamide did not induce apoptosis effectively in K562 cells. On the other hand, in normal human quiescent lymphocytes, the apoptosis was not induced by these compounds at the same concentrations. It is suggested that these compounds may induce apoptosis mainly in tumor cells. The change of intracellular peroxide levels was observed in the early phase of apoptosis induced by niacin-related compounds. We expect to make use of niacin-related compounds in the field of medicine. |
| 巻・号 | 64(6) |
| ページ | 1142-6 |
| 公開日 | 2000-6-1 |
| DOI | 10.1271/bbb.64.1142 |
| PMID | 10923782 |
| MeSH | Antineoplastic Agents / pharmacology Apoptosis / drug effects* Humans K562 Cells Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology Lymphocytes / cytology* Lymphocytes / drug effects* Lymphocytes / metabolism Niacin / analogs & derivatives* Niacin / pharmacology Niacinamide / pharmacology Peroxides / metabolism Picolinic Acids / pharmacology Reactive Oxygen Species / metabolism |
| IF | 1.516 |
| 引用数 | 15 |
| WOS 分野 | CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) |