論文 - 詳細
| RRC ID | 39546 |
|---|---|
| 著者 | Togari A, Mogi M, Arai M, Yamamoto S, Koshihara Y. |
| タイトル | Expression of mRNA for axon guidance molecules, such as semaphorin-III, netrins and neurotrophins, in human osteoblasts and osteoclasts. |
| ジャーナル | Brain Res |
| Abstract |
In the present study, we demonstrated the constitutive expression of diffusible axon guidance molecules such as neurotrophins, semaphorin-III, netrin-1, and netrin-2-like protein, which are known to function as a chemoattractant and/or chemorepellent for growing nerve fibers, in human osteoblastic and osteoclastic cells. The findings, obtained by RT-PCR, ELISA, and Western blot analysis suggest the extension of axons of peripheral sensory and sympathetic neurons to osteoblastic and osteoclastic cells and the possible neural regulation of bone metabolism in these osteogenic cells. |
| 巻・号 | 878(1-2) |
| ページ | 204-9 |
| 公開日 | 2000-9-29 |
| DOI | 10.1016/s0006-8993(00)02700-1 |
| PII | S0006-8993(00)02700-1 |
| PMID | 10996153 |
| MeSH | Adult Axons / physiology* Blotting, Western Carrier Proteins / genetics* Carrier Proteins / metabolism Cells, Cultured Enzyme-Linked Immunosorbent Assay Humans Male Nerve Growth Factors / genetics* Nerve Growth Factors / metabolism Nerve Tissue Proteins / genetics* Nerve Tissue Proteins / metabolism Netrin-1 Osteoblasts / metabolism* Osteoclasts / metabolism* RNA, Messenger / metabolism* Reverse Transcriptase Polymerase Chain Reaction Semaphorin-3A* Tumor Suppressor Proteins |
| IF | 2.733 |
| 引用数 | 53 |
| WOS 分野 | NEUROSCIENCES |
| リソース情報 | |
| ヒト・動物細胞 | Saos-2(RCB0428) |