論文 - 詳細
| RRC ID | 39767 |
|---|---|
| 著者 | Tabuchi S, Kume K, Aihara M, Shimizu T. |
| タイトル | Expression of lysophosphatidic acid receptor in rat astrocytes: mitogenic effect and expression of neurotrophic genes. |
| ジャーナル | Neurochem Res |
| Abstract |
Lysophosphatidic acid (LPA) is a phospholipid mediator with a variety of biological activities. It remains unknown, however, which cells in the brain express the LPA receptor. The present study was undertaken to identify cells in the rat brain expressing functional LPA receptors, and to explore biological roles of LPA in these cells. We found that the LPA receptor was most dominantly expressed in rat astrocytes, determined by LPA-induced Ca2+ imaging, and by Northern blot analyses. LPA induced a mitogenic response and expression of immediate early genes in astrocytes, through pertussis-toxin sensitive G-protein(s). LPA also stimulated the expression of various cytokine genes, including nerve growth factor, interleukin (IL)-1beta, IL-3 and IL-6. Thus, astrocytes are the major target of LPA in the brain. We propose that LPA may play important roles in neuronal development, gliosis and wound-healing process in the brain. |
| 巻・号 | 25(5) |
| ページ | 573-82 |
| 公開日 | 2000-5-1 |
| DOI | 10.1023/a:1007542532395 |
| PMID | 10905618 |
| MeSH | 3T3 Cells Animals Astrocytes / cytology Astrocytes / drug effects Astrocytes / physiology* Brain / cytology Brain / physiology Calcium / metabolism Cell Division / drug effects Cells, Cultured Cyclooxygenase 2 Embryo, Mammalian Gene Expression Regulation* / drug effects Genes, fos / drug effects* Isoenzymes / genetics Lysophospholipids / pharmacology* Mice Mice, Inbred ICR PC12 Cells Prostaglandin-Endoperoxide Synthases / genetics Rats Rats, Wistar Receptors, Cell Surface / physiology* Receptors, G-Protein-Coupled* Receptors, Lysophosphatidic Acid Transcription, Genetic / drug effects |
| IF | 3.038 |
| 引用数 | 47 |
| WOS 分野 | NEUROSCIENCES BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | NIH3T3 PC-12(RCB0009) |