Reference - Detail
| RRC ID | 39991 |
|---|---|
| Author | Barreiro-Iglesias A, Mysiak KS, Scott AL, Reimer MM, Yang Y, Becker CG, Becker T. |
| Title | Serotonin Promotes Development and Regeneration of Spinal Motor Neurons in Zebrafish. |
| Journal | Cell Rep |
| Abstract |
In contrast to mammals, zebrafish regenerate spinal motor neurons. During regeneration, developmental signals are re-deployed. Here, we show that, during development, diffuse serotonin promotes spinal motor neuron generation from pMN progenitor cells, leaving interneuron numbers unchanged. Pharmacological manipulations and receptor knockdown indicate that serotonin acts at least in part via 5-HT1A receptors. In adults, serotonin is supplied to the spinal cord mainly (90%) by descending axons from the brain. After a spinal lesion, serotonergic axons degenerate caudal to the lesion but sprout rostral to it. Toxin-mediated ablation of serotonergic axons also rostral to the lesion impaired regeneration of motor neurons only there. Conversely, intraperitoneal serotonin injections doubled numbers of new motor neurons and proliferating pMN-like progenitors caudal to the lesion. Regeneration of spinal-intrinsic serotonergic interneurons was unaltered by these manipulations. Hence, serotonin selectively promotes the development and adult regeneration of motor neurons in zebrafish. |
| Volume | 13(5) |
| Pages | 924-32 |
| Published | 2015-11-3 |
| DOI | 10.1016/j.celrep.2015.09.050 |
| PII | S2211-1247(15)01075-X |
| PMID | 26565906 |
| PMC | PMC4635313 |
| MeSH | Animals Interneurons / cytology Interneurons / drug effects Interneurons / metabolism Motor Neurons / cytology Motor Neurons / drug effects Motor Neurons / metabolism* Nerve Regeneration* Neural Stem Cells / cytology Neural Stem Cells / drug effects Neural Stem Cells / metabolism Receptor, Serotonin, 5-HT1A / metabolism* Serotonin / metabolism* Serotonin / pharmacology Spinal Cord / cytology Spinal Cord / growth & development* Spinal Cord / physiology Zebrafish |
| IF | 8.109 |
| Times Cited | 28 |
| WOS Category | CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 26 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Zebrafish | Tg（isl1:GFP)/rw0 |