Reference - Detail
| RRC ID | 40039 |
|---|---|
| Author | Akagi K, Sarhan M, Sultan AR, Nishida H, Koie A, Nakayama T, Ueda H. |
| Title | A biological timer in the fat body comprising Blimp-1, βFtz-f1 and Shade regulates pupation timing in Drosophila melanogaster. |
| Journal | Development |
| Abstract |
During the development of multicellular organisms, many events occur with precise timing. In Drosophila melanogaster, pupation occurs about 12 h after puparium formation and its timing is believed to be determined by the release of a steroid hormone, ecdysone (E), from the prothoracic gland. Here, we demonstrate that the ecdysone-20-monooxygenase Shade determines pupation timing by converting E to 20-hydroxyecdysone (20E) in the fat body, which is the organ that senses nutritional status. The timing of shade expression is determined by its transcriptional activator βFtz-f1. The βftz-f1 gene is activated after a decline in the expression of its transcriptional repressor Blimp-1, which is temporally expressed around puparium formation in response to a high titer of 20E. The expression level and stability of Blimp-1 is critical for the precise timing of pupation. Thus, we propose that Blimp-1 molecules function like sand in an hourglass in this precise developmental timer system. Furthermore, our data suggest that a biological advantage results from both the use of a transcriptional repressor for time determination and the association of developmental timing with nutritional status of the organism. |
| Volume | 143(13) |
| Pages | 2410-6 |
| Published | 2016-7-1 |
| DOI | 10.1242/dev.133595 |
| PII | dev.133595 |
| PMID | 27226323 |
| MeSH | Animals Biological Clocks* / drug effects Cytochrome P-450 Enzyme System / metabolism* DNA-Binding Proteins / metabolism* Drosophila Proteins / metabolism* Drosophila melanogaster / drug effects Drosophila melanogaster / genetics Drosophila melanogaster / growth & development* Drosophila melanogaster / metabolism* Ecdysterone / pharmacology Fat Body / drug effects Fat Body / metabolism* Gene Expression Regulation, Developmental / drug effects Models, Biological Protein Stability / drug effects Pupa / genetics Pupa / growth & development* Receptors, Steroid / metabolism* Repressor Proteins / metabolism* Time Factors |
| IF | 5.611 |
| Times Cited | 7 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | 13478R-1 13478R-2 |