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  • Search Condition : Filter (MeSH = Protein Stability / drug effects)
Species Resource Title
Human and Animal Cells OCUB-M(RCB0881) Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes.
DNA material pcDNA5/FRT/TO-SBP-eIF4A1 WT (RDB17295) , pHISMBP-eIF4A1-NTD (WT) (RDB17304) Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor.
Human and Animal Cells HuCCT1(RCB1960) , TFK-1(RCB2537) Jab1 Silencing Inhibits Proliferation and Sensitizes to Cisplatin in Biliary Tract Cancer.
Human and Animal Cells ATDC5(RCB0565) Nkx3.2 induces oxygen concentration-independent and lysosome-dependent degradation of HIF-1α to modulate hypoxic responses in chondrocytes.
Human and Animal Cells CW-2(RCB0778) Overcoming resistance to HER2 inhibitors through state-specific kinase binding.
Human and Animal Cells MC3T3-E1(RCB1126) Increasing participation of sclerostin in postnatal bone development, revealed by three-dimensional immunofluorescence morphometry.
Drosophila 13478R-1 , 13478R-2 A biological timer in the fat body comprising Blimp-1, βFtz-f1 and Shade regulates pupation timing in Drosophila melanogaster.
Prokaryotes E. coli Effect of signal peptide on stability and folding of Escherichia coli thioredoxin.
Prokaryotes E. coli The action of cardiolipin on the bacterial translocon.
Yeast FY7283 , FY8156 , FY11064 , FY7031 , FY10302 , FY11545 , FY8317 Caffeine stabilizes Cdc25 independently of Rad3 in Schizosaccharomyces pombe contributing to checkpoint override.
DNA material His-Xpress-RALT (RDB012225) , Flag-Chk1 (1-365) (RDB012229) , His-Xpress-RALT S250A mutant (RDB012226) , SNAP-RALT (RDB012227) , SNAP-RALT S250A mutant (RDB012228) , Flag-Chk1 (1-365) K38M mutant (RDB012230) Chk1-mediated phosphorylation of receptor-associated late transducer at serine 250 increases its stability by stimulating its interaction with 14-3-3.
Arabidopsis / Cultured plant cells, genes pda14224 The Arabidopsis ABA-activated kinase OST1 phosphorylates the bZIP transcription factor ABF3 and creates a 14-3-3 binding site involved in its turnover.
Human and Animal Cells COS-7(RCB0539) Cadmium interferes with the degradation of ATF5 via a post-ubiquitination step of the proteasome degradation pathway.