RRC ID 4065
著者 Liang H, Yao N, Song JT, Luo S, Lu H, Greenberg JT.
タイトル Ceramides modulate programmed cell death in plants.
ジャーナル Genes Dev
Abstract The balance between the bioactive sphingolipid ceramide and its phosphorylated derivative has been proposed to modulate the amount of programmed cell death (PCD) in eukaryotes. We characterized the first ceramide kinase (CERK) mutant in any organism. The Arabidopsis CERK mutant, called accelerated cell death 5, accumulates CERK substrates and shows enhanced disease symptoms during pathogen attack and apoptotic-like cell death dependent on defense signaling late in development. ACD5 protein shows high specificity for ceramides in vitro. Strikingly, C2 ceramide induces, whereas its phosphorylated derivative partially blocks, plant PCD, supporting a role for ceramide phosphorylation in modulating cell death in plants.
巻・号 17(21)
ページ 2636-41
公開日 2003-11-1
DOI 10.1101/gad.1140503
PII 1140503
PMID 14563678
PMC PMC280613
MeSH Apoptosis / physiology* Arabidopsis / metabolism* Ceramides / metabolism*
IF 9.527
引用数 237
WOS 分野 GENETICS & HEREDITY DEVELOPMENTAL BIOLOGY CELL BIOLOGY
リソース情報
シロイヌナズナ / 植物培養細胞・遺伝子 pda00534