RRC ID 4068
Author Yanase S, Onodera A, Tedesco P, Johnson TE, Ishii N.
Title SOD-1 deletions in Caenorhabditis elegans alter the localization of intracellular reactive oxygen species and show molecular compensation.
Journal J. Gerontol. A Biol. Sci. Med. Sci.
Abstract Superoxide dismutase (SOD) is an enzyme that catalytically removes the superoxide radical (*O2-) and protects organisms from oxidative damage during normal aging. We demonstrate that not only the cytosolic *O2- level but also the mitochondrial *O2- level increases in the deletion mutants of sod-1 gene encoding Cu/Zn SOD in Caenorhabditis elegans (C. elegans). Interestingly, this suggests that the activity of SOD-1, which so far has been thought to act mainly in cytoplasm, helps to control the detoxification of *O2- also in the mitochondria. We also found functional compensation by other SODs, especially the sod-5 gene, which was induced several fold in the mutants. Therefore, the possibility exists that the compensative expression of sod-5 gene in the sod-1 deficit is associated with the insulin/insulin-like growth factor-1 (Ins/IGF-1) signaling pathway, which regulates longevity and stress resistance of C. elegans because the sod-5 gene may be a target of the pathway.
Volume 64(5)
Pages 530-9
Published 2009-5
DOI 10.1093/gerona/glp020
PII glp020
PMID 19282511
MeSH Animals Caenorhabditis elegans Gene Expression Regulation, Enzymologic* Longevity / genetics* Mitochondria / enzymology* Reactive Oxygen Species / metabolism* Superoxide Dismutase / genetics* Superoxide Dismutase-1
IF 4.902
Times Cited 27
WOS Category GERONTOLOGY GERIATRICS & GERONTOLOGY
Resource
C.elegans tm776 tm783