RRC ID 4101
Author Tanimoto M, Ota Y, Horikawa K, Oda Y.
Title Auditory input to CNS is acquired coincidentally with development of inner ear after formation of functional afferent pathway in zebrafish.
Journal J. Neurosci.
Abstract Auditory perception in vertebrates depends on transduction of sound into neural signals in the inner ear hair cells (HCs) and on transmission of these signals to the brain through auditory (VIIIth) nerve afferents. To investigate the developmental acquisition of auditory inputs by the CNS, we have electrophysiologically and morphologically examined the process of acquisition of auditory responsiveness by zebrafish macular HCs and the Mauthner cells (M-cells) in vivo. The M-cells are a paired large reticulospinal neurons in the hindbrain; they receive direct inputs from the VIIIth nerve afferents and initiate an acoustic startle response. Whole-cell recordings from the M-cells showed that sound-evoked postsynaptic currents were first observed around 40 h postfertilization (hpf); during subsequent development, onset latency decreased and amplitude increased. The appearance and development of microphonic potentials in the inner ear coincided with those of the acoustic responses of the M-cell, whereas the functional auditory circuits from the macular HCs to the M-cell were already formed at 27 hpf. These results suggest that the functional maturation of inner ear after formation of the auditory pathway is a critical process in the acquisition of auditory inputs by CNS neurons.
Volume 29(9)
Pages 2762-7
Published 2009-3-4
DOI 10.1523/JNEUROSCI.5530-08.2009
PII 29/9/2762
PMID 19261871
MeSH Acoustic Stimulation Afferent Pathways / growth & development* Animals Animals, Genetically Modified Auditory Pathways / growth & development* Central Nervous System / growth & development* Cochlear Microphonic Potentials / physiology Ear, Inner / growth & development* Electrophysiology Evoked Potentials, Auditory / physiology Immunohistochemistry Neurons / physiology Vestibulocochlear Nerve / growth & development Zebrafish / physiology*
IF 5.971
Times Cited 23
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