Reference - Detail
|Title||Transgenic zebrafish expressing fluorescent proteins in central nervous system neurons.|
|Journal||Dev. Growth Differ.|
Zebrafish is a powerful model system for investigations of vertebrate neural development. The animal has also become an important model for studies of neuronal function. Both in developmental and functional studies, transgenic zebrafish expressing fluorescent proteins in central nervous system neurons have been playing important roles. We review here the methods for producing transgenic zebrafish. Recent advances in transposon- or bacterial artificial chromosome-based transgenesis greatly facilitate the creation of useful lines. We also present our study on alx-positive neurons to reveal how transgenic zebrafish expressing fluorescent proteins in a specific class of neurons can be used to investigate their development and function.
|MeSH||Animals Animals, Genetically Modified* Central Nervous System / metabolism* Chromosomes, Artificial, Bacterial Fluorescent Dyes / pharmacology Genetic Techniques Green Fluorescent Proteins / metabolism Luminescent Proteins / metabolism Luminescent Proteins / pharmacology Models, Biological Models, Genetic Neurons / metabolism Transgenes Zebrafish / genetics*|
|WOS Category||DEVELOPMENTAL BIOLOGY CELL BIOLOGY|