RRC ID 4141
Author Rubinstein AL.
Title Zebrafish assays for drug toxicity screening.
Journal Expert Opin Drug Metab Toxicol
Abstract Zebrafish are vertebrate organisms that are of growing interest for preclinical drug discovery applications. Zebrafish embryos develop most of the major organ systems present in mammals, including the cardiovascular, nervous and digestive systems, in < 1 week. Additional characteristics that make them advantageous for compound screening are their small size, transparency and ability to absorb compounds through the water. Furthermore, gene function analysis with antisense technology is now routine procedure. Thus, it is relatively simple to assess whether compounds or gene knockdowns cause toxic effects in zebrafish. Assays are being developed to exploit the unique characteristics of zebrafish for pharmacological toxicology. This review discusses assays that may be used to assess in vivo toxicity and provides examples of compounds known to be toxic to humans that have been demonstrated to function similarly in zebrafish.
Volume 2(2)
Pages 231-40
Published 2006-4
DOI 10.1517/17425255.2.2.231
PMID 16866609
MeSH Animals Animals, Genetically Modified Drug Evaluation, Preclinical / methods* Drug Evaluation, Preclinical / trends Forecasting Humans Models, Animal* Toxicity Tests / methods* Toxicity Tests / trends Zebrafish / embryology Zebrafish / genetics* Zebrafish / growth & development
IF 3.151
Times Cited 125
WOS Category PHARMACOLOGY & PHARMACY TOXICOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY
Resource
Zebrafish Review