RRC ID |
41458
|
著者 |
Takanami I, Takeuchi K, Watanabe H, Yanagawa T, Takagishi K.
|
タイトル |
Autocrine motility factor receptor gene expression and cell motility in lung cancer cell lines.
|
ジャーナル |
Oncol Rep
|
Abstract |
The cell motility of tumor cells is an integral component of tumor invasion and metastasis. Autocrine motility factor (AMF) stimulates cell motility via a receptor (R)-mediated signal pathway. We studied the correlation between level of AMF-R gene expression by reverse transcription-polymerase chain reaction and cell motility by phagokinetic track assay with or without AMF in lung cancer cell lines. Lung cancer cell lines with higher AMF-R gene expression tended to have greater cell motility than those with lower AMF-R gene expression with or without AMF. Most of lung cancer cell lines showed significantly increased motility with the stimulation of AMF. We conclude that the presence of higher AMF-R gene expression and tumor cell motility via receptor in response to the stimulation of AMF could be an important aspect in the invasion and metastasis of lung cancer cell lines.
|
巻・号 |
9(1)
|
ページ |
125-8
|
公開日 |
2002-1-1
|
PMID |
11748469
|
MeSH |
Carcinoma, Non-Small-Cell Lung / genetics*
Carcinoma, Non-Small-Cell Lung / metabolism
Cell Movement
DNA Primers / chemistry
Gene Expression
Glucose-6-Phosphate Isomerase / pharmacology
HeLa Cells
Humans
Lung Neoplasms / genetics*
Lung Neoplasms / metabolism
Receptors, Autocrine Motility Factor
Receptors, Cytokine / genetics*
Receptors, Cytokine / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Tumor Cells, Cultured / metabolism
Ubiquitin-Protein Ligases
|
IF |
3.417
|
引用数 |
3
|
WOS 分野
|
ONCOLOGY
|
リソース情報 |
ヒト・動物細胞 |
|