| RRC ID |
41539
|
| 著者 |
Nakai J, Kawada K, Nagata S, Kuramochi K, Uchiro H, Kobayashi S, Ikekita M.
|
| タイトル |
A novel lipid compound, epolactaene, induces apoptosis: its action is modulated by its side chain structure.
|
| ジャーナル |
Biochim Biophys Acta
|
| Abstract |
A novel lipid compound, epolactaene, was isolated from the culture supernatant of Penicillium sp. 1689-P and it has already been reported that it induced neurite outgrowth in a human neuroblastoma cell line. In this study, we first investigated the effects of epolactaene on a human leukemia B-cell line, BALL-1 cells, and clarified that epolactaene induces apoptosis in BALL-1 cells in a dose- and time-dependent manner. Furthermore, we focused on the side chain structure of epolactaene, and chemically synthesized epolactaene derivatives. One derivative, which has a straight long alkyl chain as its side chain, induced apoptosis more effectively than epolactaene. On the other hand, other derivatives with a short alkyl side chain had weaker apoptosis-inducing actions. A good correlation was found between the apoptosis-inducing action of these compounds and their octanol/water partition coefficients (log P). These results suggested that the apoptosis-inducing activities of epolactaene and its derivatives were related to the hydrophobicity of these compounds; so that side chain structure of epolactaene is very important for its apoptosis-inducing activities. These apoptosis-inducing actions of epolactaene and its derivatives were also observed in various blood tumor cell lines and normal lymphocytes.
|
| 巻・号 |
1581(1-2)
|
| ページ |
1-10
|
| 公開日 |
2002-3-15
|
| DOI |
10.1016/s1388-1981(01)00169-x
|
| PII |
S138819810100169X
|
| PMID |
11960746
|
| MeSH |
Apoptosis*
Cell Survival / drug effects
Dose-Response Relationship, Drug
Epoxy Compounds / chemistry*
Epoxy Compounds / pharmacology*
Humans
Hydrophobic and Hydrophilic Interactions
Jurkat Cells
Kinetics
Leukemia, B-Cell / pathology
Lipids / chemistry
Lipids / pharmacology
Lymphocytes / drug effects
Polyenes / chemistry*
Polyenes / pharmacology*
Tumor Cells, Cultured
U937 Cells
|
| IF |
3.411
|
| 引用数 |
23
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
BALL-1(RCB0256)
Jurkat(RCB0806)
Hep G2 |
