RRC ID 41675
Author Nozawa Y, Sakai N, Matsumoto K, Mizoue K.
Title A novel neuritogenic compound, NGA0187.
Journal J Antibiot (Tokyo)
Abstract A new neuritogenic compound NGA0187 was isolated from the fermentation broth of Acremonium sp. TF-0356. The structure of NGA0187 was determined by means of spectroscopic analysis and X-Ray diffraction. NGA0187 induced significant neurite outgrowth in PC12 cells. However, survival effect of NGA0187 on the primary culture of cerebral cortical neurons was not observed.
Volume 55(7)
Pages 629-34
Published 2002-7-1
DOI 10.7164/antibiotics.55.629
PMID 12243452
MeSH Agaricales / chemistry* Agaricales / classification Agaricales / metabolism Animals Cerebral Cortex / cytology Cerebral Cortex / drug effects Crystallography, X-Ray Drug Evaluation, Preclinical Fermentation Magnetic Resonance Spectroscopy Molecular Structure Nerve Growth Factors / chemistry* Nerve Growth Factors / isolation & purification Nerve Growth Factors / metabolism Nerve Growth Factors / pharmacology* Neurites / drug effects* Neurons / cytology Neurons / drug effects PC12 Cells Rats Rats, Wistar Triterpenes / chemistry* Triterpenes / isolation & purification Triterpenes / pharmacology*
IF 2.446
Times Cited 17
WOS Category PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY IMMUNOLOGY MICROBIOLOGY
Resource
Human and Animal Cells