|Author||Nozawa Y, Sakai N, Matsumoto K, Mizoue K.|
|Title||A novel neuritogenic compound, NGA0187.|
|Journal||J Antibiot (Tokyo)|
A new neuritogenic compound NGA0187 was isolated from the fermentation broth of Acremonium sp. TF-0356. The structure of NGA0187 was determined by means of spectroscopic analysis and X-Ray diffraction. NGA0187 induced significant neurite outgrowth in PC12 cells. However, survival effect of NGA0187 on the primary culture of cerebral cortical neurons was not observed.
|MeSH||Agaricales / chemistry* Agaricales / classification Agaricales / metabolism Animals Cerebral Cortex / cytology Cerebral Cortex / drug effects Crystallography, X-Ray Drug Evaluation, Preclinical Fermentation Magnetic Resonance Spectroscopy Molecular Structure Nerve Growth Factors / chemistry* Nerve Growth Factors / isolation & purification Nerve Growth Factors / metabolism Nerve Growth Factors / pharmacology* Neurites / drug effects* Neurons / cytology Neurons / drug effects PC12 Cells Rats Rats, Wistar Triterpenes / chemistry* Triterpenes / isolation & purification Triterpenes / pharmacology*|
|WOS Category||PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY IMMUNOLOGY MICROBIOLOGY|
|Human and Animal Cells|