Reference - Detail
| RRC ID | 41725 |
|---|---|
| Author | Kinjyo I, Hanada T, Inagaki-Ohara K, Mori H, Aki D, Ohishi M, Yoshida H, Kubo M, Yoshimura A. |
| Title | SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. |
| Journal | Immunity |
| Abstract |
Bacterial lipopolysaccharide (LPS) triggers innate immune responses through Toll-like receptor (TLR) 4. We show here that the suppressor of cytokine-signaling-1 (SOCS1/JAB) is rapidly induced by LPS and negatively regulates LPS signaling. SOCS1(+/-) mice or SOCS1(-/-) mice with interferon-gamma (IFNgamma)-deficient background were more sensitive to LPS-induced lethal effects than were wild-type littermates. LPS-induced NO(2)(-) synthesis and TNFalpha production were augmented in SOCS1(-/-) macrophages. Furthermore, LPS tolerance, a protection mechanism against endotoxin shock, was also strikingly reduced in SOCS1(-/-) cells. LPS-induced I-kappaB and p38 phosphorylation was upregulated in SOCS1(-/-) macrophages, and forced expression of SOCS1 suppressed LPS-induced NF-kappaB activation. Thus, SOCS1 directly suppresses TLR4 signaling and modulates innate immunity. |
| Volume | 17(5) |
| Pages | 583-91 |
| Published | 2002-11-1 |
| DOI | 10.1016/s1074-7613(02)00446-6 |
| PII | S1074-7613(02)00446-6 |
| PMID | 12433365 |
| MeSH | Animals Carrier Proteins / physiology* Cells, Cultured Drosophila Proteins* Lipopolysaccharides / pharmacology Macrophage Activation / drug effects Macrophage Activation / physiology* Macrophages, Peritoneal / physiology* Membrane Glycoproteins / physiology Mice Mice, Inbred C57BL NF-kappa B / physiology Phosphorylation Receptors, Cell Surface / physiology Repressor Proteins* Signal Transduction / drug effects Signal Transduction / physiology Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins Toll-Like Receptor 4 Toll-Like Receptors |
| IF | 22.553 |
| Times Cited | 490 |
| WOS Category | IMMUNOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 55 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | RAW 264(RCB0535) |