Reference - Detail
| RRC ID | 41747 |
|---|---|
| Author | Meselhy MR. |
| Title | Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents. |
| Journal | Phytochemistry |
| Abstract |
Three new (1-3) and five known compounds (4-8) were isolated from the oleogum resin of Commiphora wightii (Arnott.) Bhanol. Their structures were elucidated by spectroscopic and chemical methods. The MeOH extract and the EtOAc-sol. fraction were found to demonstrate significant inhibition of NO formation in lipopolysaccharide (LPS)-activated murine macrophages J774.1 in vitro (IC(50) values of 16.4 and 12.8 microg/ml, respectively). When compared with curcumin (IC(50) value of 12.3 microM), Z- and E-Guggulsterones (4 and 5, respectively) were the most potent inhibitors of NO production (IC(50) values of 1.1 and 3.3 microM, respectively), followed by myrrhanol A (7) and myrrhanone A (8) (IC(50) values of 21.1 and 42.3 microM, respectively). Guggulsterone-M (1) and its didehydro derivative (2) were weak inhibitors, while guggulsterols I (6) and Y (3) were inactive (IC(50) >500 microM). |
| Volume | 62(2) |
| Pages | 213-8 |
| Published | 2003-1-1 |
| DOI | 10.1016/s0031-9422(02)00388-6 |
| PII | S0031942202003886 |
| PMID | 12482459 |
| MeSH | Animals Cells, Cultured Commiphora / chemistry* Inhibitory Concentration 50 Lipopolysaccharides / pharmacology* Macrophages / drug effects Macrophages / metabolism Magnetic Resonance Spectroscopy Mice Molecular Structure Nitric Oxide / metabolism* Resins, Plant / chemistry* Resins, Plant / pharmacology* |
| IF | 3.044 |
| Times Cited | 55 |
| WOS Category | PLANT SCIENCES BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | J774.1(RCB0434) |