論文 - 詳細
| RRC ID | 41747 |
|---|---|
| 著者 | Meselhy MR. |
| タイトル | Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents. |
| ジャーナル | Phytochemistry |
| Abstract |
Three new (1-3) and five known compounds (4-8) were isolated from the oleogum resin of Commiphora wightii (Arnott.) Bhanol. Their structures were elucidated by spectroscopic and chemical methods. The MeOH extract and the EtOAc-sol. fraction were found to demonstrate significant inhibition of NO formation in lipopolysaccharide (LPS)-activated murine macrophages J774.1 in vitro (IC(50) values of 16.4 and 12.8 microg/ml, respectively). When compared with curcumin (IC(50) value of 12.3 microM), Z- and E-Guggulsterones (4 and 5, respectively) were the most potent inhibitors of NO production (IC(50) values of 1.1 and 3.3 microM, respectively), followed by myrrhanol A (7) and myrrhanone A (8) (IC(50) values of 21.1 and 42.3 microM, respectively). Guggulsterone-M (1) and its didehydro derivative (2) were weak inhibitors, while guggulsterols I (6) and Y (3) were inactive (IC(50) >500 microM). |
| 巻・号 | 62(2) |
| ページ | 213-8 |
| 公開日 | 2003-1-1 |
| DOI | 10.1016/s0031-9422(02)00388-6 |
| PII | S0031942202003886 |
| PMID | 12482459 |
| MeSH | Animals Cells, Cultured Commiphora / chemistry* Inhibitory Concentration 50 Lipopolysaccharides / pharmacology* Macrophages / drug effects Macrophages / metabolism Magnetic Resonance Spectroscopy Mice Molecular Structure Nitric Oxide / metabolism* Resins, Plant / chemistry* Resins, Plant / pharmacology* |
| IF | 3.044 |
| 引用数 | 55 |
| WOS 分野 | PLANT SCIENCES BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | J774.1(RCB0434) |