Reference - Detail
| RRC ID | 41753 |
|---|---|
| Author | Yamashita Y, Shimada M, Harimoto N, Rikimaru T, Shirabe K, Tanaka S, Sugimachi K. |
| Title | Histone deacetylase inhibitor trichostatin A induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells. |
| Journal | Int J Cancer |
| Abstract |
Remodeling of the chromatin template by inhibition of HDAC activities represents a potential transcriptional therapy for neoplastic disease. A number of HDAC inhibitors that modulate in vitro cell growth and differentiation have been developed. We analyzed the effects of TSA, a specific and potent HDAC inhibitor, on the human hepatoma cell lines HepG2 and Huh-7. TSA increased levels of acetylated histones H3 and H4 in both HepG2 and Huh-7. It inhibited cell proliferation in vitro and induced G(0)/G(1) arrest in HepG2 and apoptosis in Huh-7. Gene expression of liver-specific functions and liver-enriched transcription factors was upregulated by TSA. TSA upregulated the ammonia removal rate and the albumin synthesis rate of HepG2 and Huh-7. Our results indicate that TSA can induce cell-cycle arrest/apoptosis and hepatocyte differentiation in human liver cancer cell lines. |
| Volume | 103(5) |
| Pages | 572-6 |
| Published | 2003-2-20 |
| DOI | 10.1002/ijc.10699 |
| PMID | 12494463 |
| MeSH | Albumins / metabolism Ammonia / metabolism Apoptosis / drug effects* Carcinoma, Hepatocellular / enzymology Carcinoma, Hepatocellular / pathology* Cell Cycle / drug effects Cell Differentiation / drug effects Cell Division / drug effects Dose-Response Relationship, Drug Enzyme Inhibitors / pharmacology* Gene Expression Regulation, Neoplastic Hepatocytes / drug effects* Hepatocytes / metabolism Histone Deacetylase Inhibitors* Histones / metabolism Humans Hydroxamic Acids / pharmacology* Liver Neoplasms / enzymology Liver Neoplasms / pathology* Neoplasm Proteins / genetics Neoplasm Proteins / metabolism* Tumor Cells, Cultured / drug effects Tumor Cells, Cultured / enzymology Tumor Cells, Cultured / pathology |
| IF | 5.145 |
| Times Cited | 132 |
| WOS Category | ONCOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | Hep G2 HuH-7(RCB1366) |