論文 - 詳細
| RRC ID | 41772 |
|---|---|
| 著者 | Nishida S, Kikuichi S, Haga H, Yoshioka S, Tsubaki M, Fujii K, Irimajiri K. |
| タイトル | Apoptosis-inducing effect of a new bisphosphonate, YM529, on various hematopoietic tumor cell lines. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
In recent years, it has been reported that bisphosphonates inhibited the cell cycle of myeloma cells to inhibit cell proliferation directly, and it was also reported that bisphosphonates induced apoptosis of myeloma cells in vitro. Recently, YM529 was developed as a new third-generation bisphosphonate. In our experiment, we investigated whether YM529 showed an antitumor effect on hematopoietic tumor cell lines other than myeloma, and we compared YM529 with YM175, which had a relatively more potent antitumor effect than that of existing bisphosphonates. We found that YM529 inhibited cell proliferation in various hematopoietic tumor cell lines (acute promyelocytic leukemia cell line HL-60, chronic myeloid leukemia cell line K562, histiocytic lymphoma cell line U937, lymphoblastic leukemia T cell line Jurkat, acute lymphoblastic leukemia T cell line MOLT-4, lymphoblastic leukemia B cell line CCRF-SB) including myeloma (myeloma cell line HS-Sultan) dose-dependently and time-dependently to a degree equivalent or superior to that in myeloma, and induced apoptosis at a lower concentration as compared with YM175. We confirmed many dead cells as well as apoptosis based on the detection of the nuclei with separate globular structure, the activation of caspase-3, and the decrease in mitochondrial transmembrane potential. Therefore, it is concluded that further utilization of YM529 can be expected against hematopoietic tumor cells in the future. |
| 巻・号 | 26(1) |
| ページ | 96-100 |
| 公開日 | 2003-1-1 |
| DOI | 10.1248/bpb.26.96 |
| PMID | 12520182 |
| MeSH | Apoptosis / drug effects* Apoptosis / physiology Cell Survival / drug effects Cell Survival / physiology Diphosphonates / pharmacology* Diphosphonates / therapeutic use HL-60 Cells Hematologic Neoplasms / drug therapy* Hematologic Neoplasms / pathology Humans Imidazoles / pharmacology* Imidazoles / therapeutic use Intracellular Membranes / drug effects Intracellular Membranes / physiology Jurkat Cells K562 Cells Membrane Potentials / drug effects Mitochondria / drug effects Mitochondria / physiology Tumor Cells, Cultured / drug effects Tumor Cells, Cultured / physiology U937 Cells |
| IF | 1.863 |
| 引用数 | 17 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) Jurkat(RCB0806) K562 MOLT-4(RCB0206) U-937 DE-4(RCB0435) |