| RRC ID |
41850
|
| 著者 |
Hata K, Hori K, Ogasawara H, Takahashi S.
|
| タイトル |
Anti-leukemia activities of Lup-28-al-20(29)-en-3-one, a lupane triterpene.
|
| ジャーナル |
Toxicol Lett
|
| Abstract |
The cytotoxicities of 11 lupane series triterpenes against 3 human leukemias, 2 melanomas, 2 neuroblastomas and normal fibroblast cells were examined. Lupane triterpenes with a carbonyl group at C-17 (7-11) showed inhibitory effects on leukemia, melanoma and neuroblastoma cell growth. Lup-28-al-20(29)-en-3-one (8) markedly inhibited the cell growth of 3 leukemias to a greater extent than the other human cancers and normal lung fibroblast cells. The cytotoxicity profiles of 8 against human cancer cells showed that its cytotoxic effect against 3 lung cancer cell lines was strong and the cytotoxic effects against osteosarcoma, breast cancer and urinary bladder cancer cells were very weak. The morphological observations of leukemia nuclei and the gel electrophoresis analysis of DNA extracted from 8-treated leukemia cells revealed that 8 induced leukemia cell apoptosis. Furthermore, we investigated the cytotoxic effects of 8 on adriamycin (ADM)- and vincristine (VCR)-resistant K562 (K562/ADM and K562/VCR) cells. K562/ADM and K562/VCR cells showed greater resistance toward ADM and VCR when compared to parent K562 cells. However, 8 inhibited the drug-resistant K562 cell growth to the same extent as K562 cells by the induction of apoptosis.
|
| 巻・号 |
143(1)
|
| ページ |
1-7
|
| 公開日 |
2003-6-5
|
| DOI |
10.1016/s0378-4274(03)00092-4
|
| PII |
S0378427403000924
|
| PMID |
12697374
|
| MeSH |
Antineoplastic Agents, Phytogenic / pharmacology*
Apoptosis / drug effects
Cell Cycle / drug effects
DNA / drug effects
DNA Fragmentation / drug effects
DNA Topoisomerases, Type I / metabolism
Drug Resistance, Neoplasm
Fibroblasts
Humans
Leukemia / drug therapy*
Leukemia / pathology
Melanoma / drug therapy
Melanoma / pathology
Neuroblastoma / drug therapy
Neuroblastoma / pathology
Structure-Activity Relationship
Triterpenes / pharmacology
Tumor Cells, Cultured
|
| IF |
3.569
|
| 引用数 |
63
|
|
WOS 分野
|
TOXICOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
Hep G2(RCB1648)
MKN45(RCB1001)
WI-38 |
