RRC ID 41870
Author Shiba T, Nishimura D, Kawazoe Y, Onodera Y, Tsutsumi K, Nakamura R, Ohshiro M.
Title Modulation of mitogenic activity of fibroblast growth factors by inorganic polyphosphate.
Journal J Biol Chem
Abstract The proliferation of normal human fibroblast cells was enhanced by the addition of inorganic polyphosphate (poly(P)) into culture media. The mitogenic activities of acidic fibroblast growth factor (FGF-1) and basic fibroblast growth factor (FGF-2) were also enhanced by poly(P). A physical interaction between poly(P) and FGF-2 was observed, and FGF-2 was both physically and functionally stabilized by poly(P). Furthermore, poly(P) facilitated the FGF-2 binding to its cell surface receptors. Because poly(P) is widely distributed in mammalian tissues, it may be a spontaneous modulator of FGFs.
Volume 278(29)
Pages 26788-92
Published 2003-7-18
DOI 10.1074/jbc.M303468200
PII M303468200
PMID 12740373
MeSH 3T3 Cells Animals Cell Division / drug effects Cells, Cultured Culture Media Fibroblast Growth Factor 1 / metabolism Fibroblast Growth Factor 1 / pharmacology Fibroblast Growth Factor 2 / metabolism Fibroblast Growth Factor 2 / pharmacology Fibroblast Growth Factors / metabolism Fibroblast Growth Factors / pharmacology* Fibroblasts / cytology Fibroblasts / drug effects Fibroblasts / metabolism Humans Kinetics Mice Mitogens / metabolism Mitogens / pharmacology* Polyphosphates / metabolism Polyphosphates / pharmacology* Protein Binding Receptor Protein-Tyrosine Kinases / metabolism Receptor, Fibroblast Growth Factor, Type 2 Receptors, Fibroblast Growth Factor / metabolism
IF 4.238
Times Cited 98
WOS Category BIOCHEMISTRY & MOLECULAR BIOLOGY
Resource
Human and Animal Cells