論文 - 詳細
| RRC ID | 41870 |
|---|---|
| 著者 | Shiba T, Nishimura D, Kawazoe Y, Onodera Y, Tsutsumi K, Nakamura R, Ohshiro M. |
| タイトル | Modulation of mitogenic activity of fibroblast growth factors by inorganic polyphosphate. |
| ジャーナル | J Biol Chem |
| Abstract |
The proliferation of normal human fibroblast cells was enhanced by the addition of inorganic polyphosphate (poly(P)) into culture media. The mitogenic activities of acidic fibroblast growth factor (FGF-1) and basic fibroblast growth factor (FGF-2) were also enhanced by poly(P). A physical interaction between poly(P) and FGF-2 was observed, and FGF-2 was both physically and functionally stabilized by poly(P). Furthermore, poly(P) facilitated the FGF-2 binding to its cell surface receptors. Because poly(P) is widely distributed in mammalian tissues, it may be a spontaneous modulator of FGFs. |
| 巻・号 | 278(29) |
| ページ | 26788-92 |
| 公開日 | 2003-7-18 |
| DOI | 10.1074/jbc.M303468200 |
| PII | S0021-9258(20)84636-5 |
| PMID | 12740373 |
| MeSH | 3T3 Cells Animals Cell Division / drug effects Cells, Cultured Culture Media Fibroblast Growth Factor 1 / metabolism Fibroblast Growth Factor 1 / pharmacology Fibroblast Growth Factor 2 / metabolism Fibroblast Growth Factor 2 / pharmacology Fibroblast Growth Factors / metabolism Fibroblast Growth Factors / pharmacology* Fibroblasts / cytology Fibroblasts / drug effects Fibroblasts / metabolism Humans Kinetics Mice Mitogens / metabolism Mitogens / pharmacology* Polyphosphates / metabolism Polyphosphates / pharmacology* Protein Binding Receptor Protein-Tyrosine Kinases / metabolism Receptor, Fibroblast Growth Factor, Type 2 Receptors, Fibroblast Growth Factor / metabolism |
| IF | 4.238 |
| 引用数 | 98 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | BALB/3T3 clone A31(RCB0005) |