論文 - 詳細
| RRC ID | 41899 |
|---|---|
| 著者 | Uda A, Tanabayashi K, Mukai R, Terao K, Yamada A. |
| タイトル | Identification of an amino acid responsible for the CD3 polymorphism in cynomolgus monkeys (Macaca fascicularis). |
| ジャーナル | J Med Primatol |
| Abstract |
The FN18 monoclonal antibody (mAb), directed to CD3 molecules, did not react with the lymphocytes of some cynomolgus monkeys (Macaca fascicularis), because of the polymorphism of the CD3epsilon chain. The epitope recognized by the FN18 mAb was successfully expressed on COS7 cells upon transfection of plasmid DNA coding for the CD3epsilon derived from T cells of a FN18 positive cynomolgus monkey. By construction and expression of plasmid DNA encoding the mutant CD3epsilon, the amino acid residue at position 67 was demonstrated to be involved in the formation of an epitope recognizable by the FN18 mAb. |
| 巻・号 | 32(2) |
| ページ | 105-10 |
| 公開日 | 2003-4-1 |
| DOI | 10.1034/j.1600-0684.2003.00012.x |
| PII | 012 |
| PMID | 12823633 |
| MeSH | Amino Acid Sequence Animals Antibodies, Monoclonal / immunology* Antibody Specificity Base Sequence CD3 Complex / chemistry CD3 Complex / genetics* CD3 Complex / immunology* COS Cells Epitopes / genetics* Epitopes / immunology* Macaca fascicularis / genetics* Macaca fascicularis / immunology Molecular Sequence Data Mutation Polymorphism, Genetic* |
| IF | 0.553 |
| 引用数 | 4 |
| WOS 分野 | VETERINARY SCIENCES ZOOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 16 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | COS-7(RCB0539) |