Reference - Detail
| RRC ID | 4190 |
|---|---|
| Author | Tarailo M, Tarailo S, Rose AM. |
| Title | Synthetic lethal interactions identify phenotypic "interologs" of the spindle assembly checkpoint components. |
| Journal | Genetics |
| Abstract |
Here, we report genetic interactions with mdf-1(gk2)/MAD1 in Caenorhabditis elegans. Nine are evolutionarily conserved or phenotypic "interologs" and two are novel enhancers, hcp-1 and bub-3. We show that HCP-1 and HCP-2, the two CENP-F-related proteins, recently implicated in the spindle assembly checkpoint (SAC) function, do not have identical functions, since hcp-1(RNAi), but not hcp-2(RNAi), enhances the lethality of the SAC mutants. |
| Volume | 177(4) |
| Pages | 2525-30 |
| Published | 2007-12-1 |
| DOI | 10.1534/genetics.107.080408 |
| PII | 177/4/2525 |
| PMID | 18073444 |
| PMC | PMC2219473 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / genetics* Cell Cycle Proteins / genetics* Chromosomal Proteins, Non-Histone / genetics* Gene Regulatory Networks Nuclear Proteins Phenotype Spindle Apparatus / genetics* |
| IF | 4.015 |
| Times Cited | 32 |
| WOS Category | GENETICS & HEREDITY |
| Resource | |
| C.elegans | tm2910 tm2815 |