Reference - Detail
| RRC ID | 41942 |
|---|---|
| Author | Sato N, Sanjuan IM, Heke M, Uchida M, Naef F, Brivanlou AH. |
| Title | Molecular signature of human embryonic stem cells and its comparison with the mouse. |
| Journal | Dev Biol |
| Abstract |
The molecular mechanism underlying pluripotency is largely unknown. Here, we provide the first global transcriptional profile of the state of "stemness" in human embryonic stem cells (HESCs). We have identified a set of 918 genes enriched in undifferentiated HESCs compared with their differentiated counterparts. These include ligand/receptor pairs and secreted inhibitors of the FGF, TGFbeta/BMP, and Wnt pathways, highlighting a prevalent role for these pathways in HESCs. Importantly, a significant number of HESCs-enriched genes, including several signaling components, are found to be intersected with published mouse embryonic stem cell data, indicating that a "core molecular program" is shared between the two pluripotent stem cells. |
| Volume | 260(2) |
| Pages | 404-13 |
| Published | 2003-8-15 |
| DOI | 10.1016/s0012-1606(03)00256-2 |
| PII | S0012160603002562 |
| PMID | 12921741 |
| MeSH | Animals Bone Morphogenetic Proteins / genetics Bone Morphogenetic Proteins / metabolism Cell Differentiation / physiology Cells, Cultured Embryo, Mammalian / cytology Expressed Sequence Tags Fibroblast Growth Factors / genetics Fibroblast Growth Factors / metabolism Gene Expression Gene Expression Profiling / methods Humans Mice Pluripotent Stem Cells / physiology Reproducibility of Results Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Stem Cells / physiology* Transforming Growth Factor beta / genetics Transforming Growth Factor beta / metabolism |
| IF | 2.896 |
| Times Cited | 355 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Resource | |
| Human and Animal Cells | |