| RRC ID |
41972
|
| 著者 |
Miyoshi N, Nakamura Y, Ueda Y, Abe M, Ozawa Y, Uchida K, Osawa T.
|
| タイトル |
Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in Human T lymphoma Jurkat cells.
|
| ジャーナル |
Cancer Lett
|
| Abstract |
The effects of the constituents isolated from ginger species including curcumin, 6-gingerol and labdane-type diterpene compounds on cell proliferation and the induction of apoptosis in the cultured human T lymphoma Jurkat cells were studied. Among the tested compounds, galanals A and B, isolated from the flower buds of a Japanese ginger, myoga (Zingiber mioga Roscoe), showed the most potent cytotoxic effect. Exposure of Jurkat human T-cell leukemia cells to galanals resulted in the induction of apoptotic cell death characterized by DNA fragmentation and caspase-3 activation. The mitochondrial damage pathway was suggested to be involved in galanal-induced apoptosis because the treatment of cells with galanals induced mitochondrial transmembrane potential (DeltaPsim) alteration and cytochrome c release. The anti-apoptotic Bcl-2 protein was downregulated by the galanal treatment together with enhancement of the Bax expression. In conclusion, the results from this study provide biological evidence that ginger-specific constituents other than curcuminoids are potential anticancer agents.
|
| 巻・号 |
199(2)
|
| ページ |
113-9
|
| 公開日 |
2003-9-25
|
| DOI |
10.1016/s0304-3835(03)00381-1
|
| PII |
S0304383503003811
|
| PMID |
12969783
|
| MeSH |
Apoptosis / drug effects*
Blotting, Western
Caspase 3
Caspases / metabolism
Catechols
Curcumin / pharmacology
Cytochromes c / metabolism
Diet*
Diterpenes / pharmacology*
Enzyme Activation / drug effects
Fatty Alcohols / pharmacology
Ginger / chemistry*
Humans
Jurkat Cells / drug effects
Jurkat Cells / metabolism
Jurkat Cells / pathology
Membrane Potentials / drug effects
Mitochondria / drug effects
Mutagens / pharmacology
Naphthalenes / pharmacology
Proto-Oncogene Proteins / metabolism
Proto-Oncogene Proteins c-bcl-2 / metabolism
Spiro Compounds / pharmacology
bcl-2-Associated X Protein
|
| IF |
7.36
|
| 引用数 |
71
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
|
