論文 - 詳細
| RRC ID | 41987 |
|---|---|
| 著者 | Nagase M, Oto J, Sugiyama S, Yube K, Takaishi Y, Sakato N. |
| タイトル | Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
Celastrol, which is a triterpene purified from Celastraceae plants, has anticancer and anti-inflammatory activities. In this study we investigated to clarify whether celastrol can induce apoptosis in a human leukemia HL-60 model system. Celastrol was found to induce apoptosis, and the rank order of the potency of celastrol and its derivatives to induce internucleosomal DNA fragmentation was found to be celastrol>cela-H>the other derivatives=vehicle control. Many anticancer agents are known to possess the ability to inhibit topoisomerase II, so the inhibitory activities of celastrol and its derivatives on topoisomerase II were also explored. The rank order of the inhibitory activity was found to be celastrol>etoposide>cela-H, indicating that the apoptosis-inducing activities of cela derivatives correspond to their inhibitory activities on topoisomerase II. These data suggested that celastrol may cause its effects such as anticancer activity by the mechanism of apoptosis along with topoisomerase II inhibition. |
| 巻・号 | 67(9) |
| ページ | 1883-7 |
| 公開日 | 2003-9-1 |
| DOI | 10.1271/bbb.67.1883 |
| PMID | 14519971 |
| MeSH | Antineoplastic Agents, Phytogenic / pharmacology Apoptosis / drug effects* DNA Fragmentation / drug effects Dose-Response Relationship, Drug Enzyme Inhibitors / chemistry Enzyme Inhibitors / pharmacology* Etoposide / pharmacology Flow Cytometry HL-60 Cells Humans Inhibitory Concentration 50 Molecular Structure Pentacyclic Triterpenes Time Factors Topoisomerase II Inhibitors* Triterpenes / chemistry Triterpenes / pharmacology* |
| IF | 1.516 |
| 引用数 | 89 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) |