論文 - 詳細
| RRC ID | 42014 |
|---|---|
| 著者 | Guerrera M, Ladisch S. |
| タイトル | N-butyldeoxynojirimycin inhibits murine melanoma cell ganglioside metabolism and delays tumor onset. |
| ジャーナル | Cancer Lett |
| Abstract |
Aberrant ganglioside metabolism is linked to tumor progression. Since ganglioside depletion reduced tumorigenicity of MEB4 murine melanoma cells, we studied N-butyldeoxynojirimycin (NB-DNJ), an imino sugar administered orally to inhibit glucosylceramide (GlcCer) synthase in patients with glycosphingolipid storage diseases, for effects on MEB4 melanoma tumor cell ganglioside metabolism, cell biology, and tumorigenesis. Here we show that 50 microM NB-DNJ reduced MEB4 cell GlcCer synthase activity (by 70%), ganglioside synthesis (by 61%), and shedding (by 37%) while ceramide concentrations and cell viability were unaffected. Partial ganglioside depletion caused a delay in tumor onset but not in tumor incidence, possibly because of rapid (48 h) ganglioside recovery. The delay in tumor development by NB-DNJ treatment of MEB4 cells provides further support for the concept of tumor cell ganglioside metabolism as a therapeutic target in cancer. |
| 巻・号 | 201(1) |
| ページ | 31-40 |
| 公開日 | 2003-11-10 |
| DOI | 10.1016/s0304-3835(03)00459-2 |
| PII | S0304383503004592 |
| PMID | 14580684 |
| MeSH | 1-Deoxynojirimycin / analogs & derivatives* 1-Deoxynojirimycin / pharmacology* Animals Cell Division / drug effects Cell Line, Tumor Ceramides / metabolism Disease Progression Dose-Response Relationship, Drug Enzyme Inhibitors / pharmacology* Gangliosides / metabolism* Glucosyltransferases / drug effects* Glucosyltransferases / metabolism Melanoma, Experimental / metabolism* Melanoma, Experimental / pathology Mice Neoplasm Transplantation |
| IF | 7.36 |
| 引用数 | 29 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MEB4(RCB1027) |