| RRC ID |
42136
|
| Author |
Nishino J, Yamashita K, Hashiguchi H, Fujii H, Shimazaki T, Hamada H.
|
| Title |
Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension.
|
| Journal |
EMBO J
|
| Abstract |
Glial cells are major components of the nervous system. The roles of these cells are not fully understood, however. We have now identified a secreted protein, designated Meteorin, that is expressed in undifferentiated neural progenitors and in the astrocyte lineage, including radial glia. Meteorin selectively promoted astrocyte formation from mouse cerebrocortical neurospheres in differentiation culture, whereas it induced cerebellar astrocytes to become radial glia. Meteorin also induced axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. These observations suggest that Meteorin plays important roles in both glial cell differentiation and axonal network formation during neurogenesis.
|
| Volume |
23(9)
|
| Pages |
1998-2008
|
| Published |
2004-5-5
|
| DOI |
10.1038/sj.emboj.7600202
|
| PII |
7600202
|
| PMID |
15085178
|
| PMC |
PMC404322
|
| MeSH |
Amino Acid Sequence
Animals
Axons / physiology*
Blotting, Northern
Cell Differentiation / genetics
Cell Differentiation / physiology*
Cells, Cultured
DNA Primers
DNA, Complementary / genetics
Humans
In Situ Hybridization
Intercellular Signaling Peptides and Proteins
Mice
Models, Biological*
Molecular Sequence Data
Nerve Tissue Proteins / genetics
Nerve Tissue Proteins / metabolism*
Nervous System / embryology*
Neuroglia / metabolism*
Neuroglia / physiology
Reverse Transcriptase Polymerase Chain Reaction
Sequence Alignment
Stem Cells / metabolism*
|
| IF |
9.889
|
| Times Cited |
68
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Human and Animal Cells |
CHO-K1(RCB0285) |
