論文 - 詳細
| RRC ID | 42211 |
|---|---|
| 著者 | Ishii T, Fujishiro M, Masuda M, Okudela K, Kitamura H, Teramoto S, Matsuse T. |
| タイトル | Nutritional deficiency affects cell cycle status and viability in A549 cells: role of p27Kip1. |
| ジャーナル | Cancer Lett |
| Abstract |
We investigated how nutritional deficiency affects cell cycle and cell viability in A549 lung adenocarcinoma cells. Deprivation of various amino acids or glucose induced cell cycle arrest and cell death in a different manner. Cell death on deprivation of these nutrients was increased by downregulating of p27Kip1 with RNA interference. It was also observed that intrinsic p27Kip1 was segregated in cytoplasm in a glucose-deprived situation. In conclusion, amino acid or glucose deprivation induced cell cycle arrest and cell death, part of which is thought to be rescued by the existence of cytoplasmic p27Kip1. |
| 巻・号 | 213(1) |
| ページ | 99-109 |
| 公開日 | 2004-9-15 |
| DOI | 10.1016/j.canlet.2004.03.022 |
| PII | S0304383504002320 |
| PMID | 15312689 |
| MeSH | Adenocarcinoma / pathology* Amino Acids / metabolism Apoptosis* Carcinoma, Non-Small-Cell Lung / pathology* Cell Cycle* Cell Cycle Proteins / biosynthesis* Cell Survival* Cyclin-Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinases / antagonists & inhibitors Down-Regulation Genes, Tumor Suppressor Glucose / metabolism Humans Lung Neoplasms / pathology* Malnutrition RNA Interference Tumor Cells, Cultured Tumor Suppressor Proteins / biosynthesis* |
| IF | 7.36 |
| 引用数 | 9 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | |