| RRC ID |
42211
|
| 著者 |
Ishii T, Fujishiro M, Masuda M, Okudela K, Kitamura H, Teramoto S, Matsuse T.
|
| タイトル |
Nutritional deficiency affects cell cycle status and viability in A549 cells: role of p27Kip1.
|
| ジャーナル |
Cancer Lett
|
| Abstract |
We investigated how nutritional deficiency affects cell cycle and cell viability in A549 lung adenocarcinoma cells. Deprivation of various amino acids or glucose induced cell cycle arrest and cell death in a different manner. Cell death on deprivation of these nutrients was increased by downregulating of p27Kip1 with RNA interference. It was also observed that intrinsic p27Kip1 was segregated in cytoplasm in a glucose-deprived situation. In conclusion, amino acid or glucose deprivation induced cell cycle arrest and cell death, part of which is thought to be rescued by the existence of cytoplasmic p27Kip1.
|
| 巻・号 |
213(1)
|
| ページ |
99-109
|
| 公開日 |
2004-9-15
|
| DOI |
10.1016/j.canlet.2004.03.022
|
| PII |
S0304383504002320
|
| PMID |
15312689
|
| MeSH |
Adenocarcinoma / pathology*
Amino Acids / metabolism
Apoptosis*
Carcinoma, Non-Small-Cell Lung / pathology*
Cell Cycle*
Cell Cycle Proteins / biosynthesis*
Cell Survival*
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases / antagonists & inhibitors
Down-Regulation
Genes, Tumor Suppressor
Glucose / metabolism
Humans
Lung Neoplasms / pathology*
Malnutrition
RNA Interference
Tumor Cells, Cultured
Tumor Suppressor Proteins / biosynthesis*
|
| IF |
7.36
|
| 引用数 |
9
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
|
