論文 - 詳細
| RRC ID | 42242 |
|---|---|
| 著者 | Konno T, Hasuda H, Ishihara K, Ito Y. |
| タイトル | Photo-immobilization of a phospholipid polymer for surface modification. |
| ジャーナル | Biomaterials |
| Abstract |
A photo-reactive polymer having a phospholipid polar group was prepared, and the polymer was photo-immobilized on polymeric surfaces, where its interactions with biocomponents were investigated. By using a photo-immobilization method, the polymer was used for surface modification of polyethylene and polypropylene, polymers whose surfaces were not treated in our previous development of the phosphorylcholine-derived polymer. The photo-reactive polymer was synthesized by a coupling reaction involving copolymer consisting of 2-methacryloyloxyethyl phosphorylcholine and methacrylic acid with 4-azidoaniline. When the polymer was unpattern immobilized on the surface, X-ray photo-electron spectroscopic analysis and static contact angle measurements were performed. It was shown that the surface was covered with phospholipid polar groups. Micropattern immobilization was carried out using a micropatterned photo-mask. Measurements using atomic force microscopy showed that the swelled micropatterned polymer was five times as thick as the dried one. Protein adsorption and platelet adhesion were reduced on the polymer-immobilized regions. Mammalian cells did not adhere, and formed aggregates on the immobilized regions. In conclusion, the photo-reactive phospholipid polymer was covalently immobilized on the conventional polymer surfaces and it tended to reduce interactions with proteins and cells. |
| 巻・号 | 26(12) |
| ページ | 1381-8 |
| 公開日 | 2005-4-1 |
| DOI | 10.1016/j.biomaterials.2004.04.047 |
| PII | S0142961204004466 |
| PMID | 15482825 |
| MeSH | Adsorption / radiation effects Animals Cell Adhesion / physiology* Cells, Cultured Coated Materials, Biocompatible / chemistry Humans Immunoglobulins / chemistry Light Materials Testing Mice Monocytes / cytology Monocytes / physiology Phospholipids / chemistry* Phospholipids / radiation effects Photochemistry / methods* Platelet Adhesiveness / physiology* Polyethylene / chemistry* Polyethylene / radiation effects Polypropylenes / chemistry* Polypropylenes / radiation effects Protein Binding Serum Albumin, Bovine / chemistry Surface Properties Tissue Engineering / methods |
| IF | 10.317 |
| 引用数 | 60 |
| WOS 分野 | ENGINEERING, BIOMEDICAL MATERIALS SCIENCE, BIOMATERIALS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |