| RRC ID |
42402
|
| 著者 |
Nishimura K, Yamashita K, Kato Y, Iwata T, Iwata K, Nishikawa T, Goto S, Hayakawa T.
|
| タイトル |
Inhibitory activity on matrix metalloproteinases and cell-proliferating activity of tissue inhibitor of metalloproteinases-1 (TIMP-1)-contrastive difference between human and bovine TIMP-1s on mouse cell proliferation.
|
| ジャーナル |
Growth Factors
|
| Abstract |
Either human or bovine TIMP-1 inhibited matrix metalloproteinase (MMP) activities, such as collagenolytic, gelatinolytic and caseinolytic, expressed by mouse cells as well as those expressed by human cells. Bovine TIMP-1 stimulated the proliferation of both human and mouse cells, but human TIMP-1 only proliferate human cells and not mouse cells indicating that the cell-proliferating activity has more strict species specificity than MMP inhibitory activity. All the results from [(3)H]thymidine incorporation, the phosphorylation of tyrosine-containing cellular proteins and extracellular-signal-regulated protein kinases supported the cell-proliferating properties of both human and bovine TIMP-1s. Human TIMP-1 seems not to bind to TIMP-1 receptors on mouse cells.
|
| 巻・号 |
23(2)
|
| ページ |
135-42
|
| 公開日 |
2005-6-1
|
| DOI |
10.1080/08977190500138772
|
| PII |
J033630738H73000
|
| PMID |
16019435
|
| MeSH |
Animals
Cattle
Cell Culture Techniques / methods
Cell Line
Cell Line, Tumor
Cell Proliferation / drug effects*
Cells, Cultured / metabolism
Cricetinae
Culture Media, Conditioned / pharmacology
Extracellular Signal-Regulated MAP Kinases / metabolism
Humans
Immunoblotting
Matrix Metalloproteinase Inhibitors*
Mice
Phosphorylation
Phosphotyrosine / chemistry
Species Specificity
Tissue Inhibitor of Metalloproteinase-1 / biosynthesis*
|
| IF |
1.543
|
| リソース情報 |
| ヒト・動物細胞 |
CHO-K1 |
