論文 - 詳細
| RRC ID | 42511 |
|---|---|
| 著者 | Wakana K, Akiyama Y, Aso T, Yuasa Y. |
| タイトル | Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis. |
| ジャーナル | Cancer Lett |
| Abstract |
To clarify the role of GATA transcription factors in ovarian carcinogenesis, we analyzed the expression and methylation states of GATA-4/-5/-6 in eight human ovarian cancer cell lines. GATA-4/-5 were methylated in three and two cell lines without their expression, respectively. Methylation of GATA-4/-5 was also detected in nine and five of 15 primary ovarian cancers, respectively. GATA-6 was not methylated in any cases. We transiently over-expressed GATA-5 in the JHOC-5 cell line using an adenovirus system, resulting in that apoptosis was induced and apoptosis-related genes, such as Apaf-1, were up-regulated. These data suggest that GATA-4/-5 may be involved in ovarian carcinogenesis. |
| 巻・号 | 241(2) |
| ページ | 281-8 |
| 公開日 | 2006-9-28 |
| DOI | 10.1016/j.canlet.2005.10.039 |
| PII | S0304-3835(05)00958-4 |
| PMID | 16337738 |
| MeSH | Adenocarcinoma, Clear Cell / genetics Adenocarcinoma, Clear Cell / metabolism Apoptosis Carcinoma, Endometrioid / genetics Carcinoma, Endometrioid / metabolism Cell Proliferation Cystadenocarcinoma, Serous / genetics Cystadenocarcinoma, Serous / metabolism DNA Methylation* DNA, Neoplasm / genetics DNA, Neoplasm / metabolism Female GATA4 Transcription Factor / genetics* GATA5 Transcription Factor / genetics* GATA6 Transcription Factor / genetics* Gene Expression Regulation, Neoplastic / physiology* Gene Silencing Humans Ovarian Neoplasms / genetics* Ovarian Neoplasms / metabolism Promoter Regions, Genetic |
| IF | 7.36 |
| 引用数 | 36 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | OMC-3(RCB0755) JHOC-5(RCB1520) HTOA(RCB0692) JHOS-3(RCB1546) |