RRC ID 42511
Author Wakana K, Akiyama Y, Aso T, Yuasa Y.
Title Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis.
Journal Cancer Lett
Abstract To clarify the role of GATA transcription factors in ovarian carcinogenesis, we analyzed the expression and methylation states of GATA-4/-5/-6 in eight human ovarian cancer cell lines. GATA-4/-5 were methylated in three and two cell lines without their expression, respectively. Methylation of GATA-4/-5 was also detected in nine and five of 15 primary ovarian cancers, respectively. GATA-6 was not methylated in any cases. We transiently over-expressed GATA-5 in the JHOC-5 cell line using an adenovirus system, resulting in that apoptosis was induced and apoptosis-related genes, such as Apaf-1, were up-regulated. These data suggest that GATA-4/-5 may be involved in ovarian carcinogenesis.
Volume 241(2)
Pages 281-8
Published 2006-9-28
DOI 10.1016/j.canlet.2005.10.039
PII S0304-3835(05)00958-4
PMID 16337738
MeSH Adenocarcinoma, Clear Cell / genetics Adenocarcinoma, Clear Cell / metabolism Apoptosis Carcinoma, Endometrioid / genetics Carcinoma, Endometrioid / metabolism Cell Proliferation Cystadenocarcinoma, Serous / genetics Cystadenocarcinoma, Serous / metabolism DNA Methylation* DNA, Neoplasm / genetics DNA, Neoplasm / metabolism Female GATA4 Transcription Factor / genetics* GATA5 Transcription Factor / genetics* GATA6 Transcription Factor / genetics* Gene Expression Regulation, Neoplastic / physiology* Gene Silencing Humans Ovarian Neoplasms / genetics* Ovarian Neoplasms / metabolism Promoter Regions, Genetic
IF 6.508
Times Cited 36
Human and Animal Cells