RRC ID |
42511
|
著者 |
Wakana K, Akiyama Y, Aso T, Yuasa Y.
|
タイトル |
Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis.
|
ジャーナル |
Cancer Lett
|
Abstract |
To clarify the role of GATA transcription factors in ovarian carcinogenesis, we analyzed the expression and methylation states of GATA-4/-5/-6 in eight human ovarian cancer cell lines. GATA-4/-5 were methylated in three and two cell lines without their expression, respectively. Methylation of GATA-4/-5 was also detected in nine and five of 15 primary ovarian cancers, respectively. GATA-6 was not methylated in any cases. We transiently over-expressed GATA-5 in the JHOC-5 cell line using an adenovirus system, resulting in that apoptosis was induced and apoptosis-related genes, such as Apaf-1, were up-regulated. These data suggest that GATA-4/-5 may be involved in ovarian carcinogenesis.
|
巻・号 |
241(2)
|
ページ |
281-8
|
公開日 |
2006-9-28
|
DOI |
10.1016/j.canlet.2005.10.039
|
PII |
S0304-3835(05)00958-4
|
PMID |
16337738
|
MeSH |
Adenocarcinoma, Clear Cell / genetics
Adenocarcinoma, Clear Cell / metabolism
Apoptosis
Carcinoma, Endometrioid / genetics
Carcinoma, Endometrioid / metabolism
Cell Proliferation
Cystadenocarcinoma, Serous / genetics
Cystadenocarcinoma, Serous / metabolism
DNA Methylation*
DNA, Neoplasm / genetics
DNA, Neoplasm / metabolism
Female
GATA4 Transcription Factor / genetics*
GATA5 Transcription Factor / genetics*
GATA6 Transcription Factor / genetics*
Gene Expression Regulation, Neoplastic / physiology*
Gene Silencing
Humans
Ovarian Neoplasms / genetics*
Ovarian Neoplasms / metabolism
Promoter Regions, Genetic
|
IF |
7.36
|
引用数 |
36
|
WOS 分野
|
ONCOLOGY
|
リソース情報 |
ヒト・動物細胞 |
OMC-3(RCB0755)
JHOC-5(RCB1520)
HTOA(RCB0692)
JHOS-3(RCB1546) |