Reference - Detail
| RRC ID | 4266 |
|---|---|
| Author | Miyata S, Begun J, Troemel ER, Ausubel FM. |
| Title | DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans. |
| Journal | Genetics |
| Abstract |
To further understand how the nematode Caenorhabditis elegans defends itself against pathogen attack, we analyzed enhanced pathogen resistance (epr) mutants obtained from a forward genetic screen. We also examined several well-characterized sterile mutants that exhibit an Epr phenotype. We found that sterility and pathogen resistance are highly correlated and that resistance in both epr and sterile mutants is dependent on DAF-16 activity. Our data indicate that a DAF-16-dependent signaling pathway distinct from previously described pathways is involved in the activation of genes that confer resistance to bacterial pathogens. The timing of DAF-16-dependent gene activation in sterile mutants coincides with the onset of embryonic development in wild-type animals, suggesting that signals from developing embryos normally downregulate the immune response. |
| Volume | 178(2) |
| Pages | 903-18 |
| Published | 2008-2-1 |
| DOI | 10.1534/genetics.107.083923 |
| PII | genetics.107.083923 |
| PMID | 18245330 |
| PMC | PMC2248360 |
| MeSH | Animals Caenorhabditis elegans / embryology Caenorhabditis elegans / genetics* Caenorhabditis elegans / immunology* Caenorhabditis elegans Proteins / genetics* Chromosome Mapping Embryonic Development / genetics Female Forkhead Transcription Factors Gene Expression Regulation Genetic Complementation Test Genetic Testing Male Polymorphism, Single Nucleotide Reproduction / genetics Reproduction / immunology Reproduction / physiology* Suppression, Genetic* Transcription Factors / genetics* Transcriptional Activation |
| IF | 4.015 |
| Times Cited | 69 |
| WOS Category | GENETICS & HEREDITY |
| Resource | |
| C.elegans | tm2864 tm2593 |