Reference - Detail
| RRC ID | 4267 |
|---|---|
| Author | Mori C, Takanami T, Higashitani A. |
| Title | Maintenance of mitochondrial DNA by the Caenorhabditis elegans ATR checkpoint protein ATL-1. |
| Journal | Genetics |
| Abstract |
Here we show that inactivation of the ATR-related kinase ATL-1 results in a significant reduction in mitochondrial DNA (mtDNA) copy numbers in Caenorhabditis elegans. Although ribonucleotide reductase (RNR) expression and the ATP/dATP ratio remained unaltered in atl-1 deletion mutants, inhibition of RNR by RNAi or hydroxyurea treatment caused further reductions in mtDNA copy number. These results suggest that ATL-1 functions to maintain mtDNA independently of RNR. |
| Volume | 180(1) |
| Pages | 681-6 |
| Published | 2008-9-1 |
| DOI | 10.1534/genetics.108.090704 |
| PII | genetics.108.090704 |
| PMID | 18716329 |
| PMC | PMC2535718 |
| MeSH | Adenosine Triphosphate / chemistry Animals Ataxia Telangiectasia Mutated Proteins Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics* Chromosomes DNA, Mitochondrial* / genetics Gene Deletion* Homozygote Hydroxyurea / pharmacology Models, Biological Models, Genetic Mutation* Phosphotransferases / genetics* RNA Interference Ribonucleotide Reductases / biosynthesis Ribonucleotide Reductases / genetics |
| IF | 4.015 |
| Times Cited | 7 |
| WOS Category | GENETICS & HEREDITY |
| Resource | |
| C.elegans | tm853 |