Reference - Detail
RRC ID | 4267 |
---|---|
Author | Mori C, Takanami T, Higashitani A. |
Title | Maintenance of mitochondrial DNA by the Caenorhabditis elegans ATR checkpoint protein ATL-1. |
Journal | Genetics |
Abstract |
Here we show that inactivation of the ATR-related kinase ATL-1 results in a significant reduction in mitochondrial DNA (mtDNA) copy numbers in Caenorhabditis elegans. Although ribonucleotide reductase (RNR) expression and the ATP/dATP ratio remained unaltered in atl-1 deletion mutants, inhibition of RNR by RNAi or hydroxyurea treatment caused further reductions in mtDNA copy number. These results suggest that ATL-1 functions to maintain mtDNA independently of RNR. |
Volume | 180(1) |
Pages | 681-6 |
Published | 2008-9-1 |
DOI | 10.1534/genetics.108.090704 |
PII | genetics.108.090704 |
PMID | 18716329 |
PMC | PMC2535718 |
MeSH | Adenosine Triphosphate / chemistry Animals Ataxia Telangiectasia Mutated Proteins Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics* Chromosomes DNA, Mitochondrial* / genetics Gene Deletion* Homozygote Hydroxyurea / pharmacology Models, Biological Models, Genetic Mutation* Phosphotransferases / genetics* RNA Interference Ribonucleotide Reductases / biosynthesis Ribonucleotide Reductases / genetics |
IF | 4.015 |
Times Cited | 7 |
WOS Category | GENETICS & HEREDITY |
Resource | |
C.elegans | tm853 |