論文 - 詳細
| RRC ID | 42868 |
|---|---|
| 著者 | Takano Y, Yamauchi K, Hayakawa K, Hiramatsu N, Kasai A, Okamura M, Yokouchi M, Shitamura A, Yao J, Kitamura M. |
| タイトル | Transcriptional suppression of nephrin in podocytes by macrophages: roles of inflammatory cytokines and involvement of the PI3K/Akt pathway. |
| ジャーナル | FEBS Lett |
| Abstract |
Expression of nephrin, a crucial component of the glomerular slit diaphragm, is downregulated in patients with proteinuric glomerular diseases. Using conditionally immortalized reporter podocytes, we found that bystander macrophages as well as macrophage-derived cytokines IL-1beta and TNF-alpha markedly suppressed activity of the nephrin gene promoter in podocytes. The cytokine-initiated repression was reversible, observed on both basal and inducible expression, independent of Wilms' tumor suppressor WT1, and caused in part via activation of the phosphatidylinositol-3-kinase/Akt pathway. These results indicated a novel mechanism by which activated macrophages participate in the induction of proteinuria in glomerular diseases. |
| 巻・号 | 581(3) |
| ページ | 421-6 |
| 公開日 | 2007-2-6 |
| DOI | 10.1016/j.febslet.2006.12.051 |
| PII | S0014-5793(07)00020-8 |
| PMID | 17239861 |
| MeSH | Animals Cell Communication Cells, Cultured Cytokines / metabolism Cytokines / pharmacology Down-Regulation / drug effects Humans Inflammation Mediators / metabolism Inflammation Mediators / pharmacology Interleukin-1beta / metabolism Interleukin-1beta / pharmacology Macrophages / immunology Macrophages / metabolism* Membrane Proteins / genetics* Mice Phosphatidylinositol 3-Kinases / metabolism Podocytes / drug effects Podocytes / metabolism* Promoter Regions, Genetic Proto-Oncogene Proteins c-akt / metabolism Tumor Necrosis Factor-alpha / metabolism Tumor Necrosis Factor-alpha / pharmacology |
| IF | 3.057 |
| 引用数 | 65 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | J774.1(RCB0434) |