RRC ID 4291
Author Schott S, Ramos F, Coustham V, Palladino F.
Title HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval precursor cells.
Journal Genetics
Abstract A current model for Caenorhabditis elegans vulval cell fate specification is that SynMuv genes act redundantly in the hyp7 hypodermal syncytium to repress the LIN-3/EGF inducer and prevent ectopic vulval induction of vulva precursor cells (VPCs). Here we show that the SynMuv gene hpl-2/HP1 has an additional function in VPCs, where it may act through target genes including LIN-39/Hox.
Volume 181(2)
Pages 797-801
Published 2009-2
DOI 10.1534/genetics.108.089276
PII genetics.108.089276
PMID 19064713
PMC PMC2644966
MeSH Animals Caenorhabditis elegans / embryology* Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / antagonists & inhibitors Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Chromosomal Proteins, Non-Histone / genetics Chromosomal Proteins, Non-Histone / physiology* Embryonic Induction / genetics Embryonic Induction / physiology Embryonic Stem Cells / cytology Epidermal Growth Factor / antagonists & inhibitors Epidermal Growth Factor / genetics Epidermal Growth Factor / physiology Female Genes, Helminth Giant Cells / cytology Mutation RNA Interference Vulva / cytology Vulva / embryology*
IF 4.075
Times Cited 3
C.elegans tm1489