RRC ID 42936
Author Hirata H, Murakami Y, Miyamoto Y, Tosaka M, Inoue K, Nagahashi A, Jakt LM, Asahara T, Iwata H, Sawa Y, Kawamata S.
Title ALCAM (CD166) is a surface marker for early murine cardiomyocytes.
Journal Cells Tissues Organs
Abstract ALCAM (activated leukocyte cell adhesion molecule, CD166) belongs to the immunoglobulin superfamily and is involved in axon guidance, hematopoiesis, immune response and tumor metastasis. During embryogenesis, mRNA encoding ALCAM was expressed in the cardiac crescent and the neural groove at embryonic day (E) 7.75 and predominately in the tubular heart at E8.5. A newly generated monoclonal antibody against the ALCAM molecule (ALC-48) exclusively stained cardiomyocytes at E8.25-10.5. However, ALCAM expression was lost by cardiomyocytes by E12.5 and its expression shifts to a variety of organs during later stages. ALCAM was found to be a prominent surface marker for cardiomyocytes in early embryonic hearts. The transient expression of ALCAM during early developmental stages marks specific developmental stages in cardiomyocyte differentiation.
Volume 184(3-4)
Pages 172-80
Published 2006-1-1
DOI 10.1159/000099624
PII 000099624
PMID 17409743
MeSH Activated-Leukocyte Cell Adhesion Molecule / analysis* Animals Antibodies, Monoclonal Biomarkers / analysis Cell Line Cell Membrane / ultrastructure Fetal Heart / cytology Fetus Humans Immunohistochemistry Kidney Mice Muscle Cells / cytology* Myocardium / cytology*
IF 1.333
Times Cited 26
Human and Animal Cells